ArticleRespiratory research2025
Neutrophils are involved in the development and outcomes of plastic bronchitis associated with Mycoplasma pneumoniae pneumonia.
Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Associations of Serum CIRP and CXCL5 With Prognosis and Neutrophil Extracellular Traps in Pediatric Mycoplasma pneumoniae Pneumonia.The clinical respiratory journal · 2026Article
- Complete Blood Count-Derived Inflammatory Markers in Pediatric Lower Respiratory Tract Infection: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Risk factors and construction of prediction model for plastic bronchitis in children withTranslational pediatrics · 2026Article
- Factors associated with in-hospital mortality and treatment withdrawal in mechanically ventilated children with severe pneumonia: a retrospective cohort study.Translational pediatrics · 2026Article
- Article
- Host immune dysfunction and Mycoplasma pneumoniae immune evasion: dual drivers of pathogenesis in Mycoplasma pneumoniae pneumonia.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Post-pandemic resurgence of Mycoplasma pneumoniae in coastal China: from seasonal waves to sustained transmission and expanded age susceptibility.BMC infectious diseases · 2026Article
- Endobronchial abnormalities and bronchoalveolar lavage findings in children with severe pneumonia andFrontiers in pediatrics · 2026Article
- The value of serum CARDS toxin and NETs formation in children with MPP.Frontiers in cellular and infection microbiology · 2026Article
- Immune dysregulation inFrontiers in immunology · 2026Review
- Early prediction of plastic bronchitis in pediatric patients withFrontiers in cellular and infection microbiology · 2026Article
- A literature review: progress in the study of plastic bronchitis.Frontiers in pediatrics · 2026Review
- Plastic bronchitis: a narrative review of the classification methods and pathogenesis.Frontiers in pediatrics · 2026Review
- Clinical risk factors and a predictive nomogram for mechanical ventilation in pediatric patients with infection-related plastic bronchitis.BMC infectious diseases · 2025Article
- Pulmonary lesion volume ratio and laboratory parameters as risk factors for plastic bronchitis in pediatric refractory Mycoplasma pneumoniae pneumonia.BMC pediatrics · 2025Article
- Mycoplasma Pneumoniae bronchiolitis and hypoxemia: A retrospective cohort study on risk and prognosis.PloS one · 2025Article
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6 authors.
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Abstract
backgroundPrevious research has demonstrated a notable increase in neutrophil counts among pediatric patients with plastic bronchitis (PB) associated with Mycoplasma pneumoniae pneumonia (MPP). However, the role of neutrophils in MPP-associated PB remains largely elusive.
methodsThis is a nested case-control study that enrolled patients diagnosed with MPP who underwent bronchoscopy in our department during the MPP pandemic from September 2023 to January 2024. We conducted an analysis of clinical characteristics, blood samples, bronchoalveolar lavage fluid (BALF), and cast specimens, correlating these factors with the development and outcomes of PB.
resultsAmong the 557 patients with MPP included in the study, 21 (3.8%) developed PB. The peripheral neutrophil count was identified as an independent risk factor for PB (OR = 3.113 [95%CI 1.050-9.224], P = 0.04) and exhibited strong predictive value for the condition (AUC = 0.885 [95%CI 0.796-0.975], P < 0.001). Notably, there was a marked presence of neutrophil infiltration and neutrophil extracellular traps (NETs) formation in the blood, BALF, and cast samples from patients with PB. Furthermore, the levels of neutrophils and NETs correlated significantly with clinical outcomes.
conclusionA high level of neutrophils poses a risk for PB and demonstrates strong predictive value for its diagnosis. Neutrophils and NETs are closely linked to the clinical outcomes of PB in patients with MPP.
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