Evidence map›Paper›PMID 40057699›Full record

ArticleCancer cell international2025

HNRNPC promotes progression of non-small cell lung cancer by maintaining TFAP2A mRNA stability.

Minghua Liao, Chunyu Li, Rui Yang, Jun Li, Ke Wu, Jiayi Zhang, Qian Zhu, Yingchang Shi, Xianming Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minghua Liao *Department of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China.
Chunyu Li *Department of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China.
Rui YangDepartment of Internal Medicine, Guiyang First People's Hospital, Guiyang, Guizhou, 550004, China.
Jun LiDepartment of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China.
Ke WuDepartment of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China.
Jiayi ZhangDepartment of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China.
Qian ZhuDepartment of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China.
Yingchang ShiDepartment of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China.
Xianming ZhangDepartment of Respiratory and Critical Medicine, The Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, China. zxm13078524367@163.com.

Funding

Basic research project of Science and Technology Department of Guizhou Province Basic of Guizhou - ZK[2022] General 450e Cultivate project 2021 for National Natural Science Foundation of China, Affiliated Hospital of Guizhou Medical University gyfynsfc-2021-33Science and Technology Fund Project of Guizhou Health Committee, China gzwjkj2020-1-052Science and Technology Fund Project of Guizhou Health Committee, China gzwjkj2021-090Science and Technology Fund Project of Guizhou Health Committee, China gzwjkj2021-096Science and Technology Support Program of Science and Technology Department of Guizhou Province Qian Ke He Zhi Cheng[2021]Yi Ban 061the Cultivate project 2021 for National Natural Science Foundation of China 20NSP038
6 · The paper itself

Abstract

backgroundHNRNPC is an RNA-binding protein that is overexpressed in a variety of cancers and is well known as an m6A "reader", but its specific function and molecular mechanism in NSCLC have not been fully understood. This study aimed to discuss molecular mechanism of HNRNPC in NSCLC.

methodsHNRNPC expression and clinically relevant data in pan-cancer and LUAD were extracted through these websites, including UALCAN, TIMER2 and GEPIA. The target gene of HNRNPC were identified through RIP-seq, meRIP-qPCR and mRNA stability test. The differential expression of target gene in NSCLC was explored by immunohistochemistry. Lentivirus was selected to knock down HNRNPC and plasmid was selected to overexpress downstream target genes. The transfection efficiency was verified by RT-qPCR and Western Blot. In vitro colony formation assay, CCK-8, wound healing, transwell assays were performed to determine the biological functions of HNRNPC and target gene in lung adenocarcinoma cells.

resultsHNRNPC can promotes the expression of TFAP2A by recognizing the m6A modification of TFAP2A mRNA and maintaining its stability, activates the TFAP2A/CTNNB1 axis, enhances EMT, and ultimately promotes the malignant process of NSCLC and promote distant metastasis of NSCLC.

conclusionsThese results supported that HNRNPC regulate TFAP2A to promote the malignant progression and EMT of NSCLC. These findings connect m6A modification with EMT, providing a new perspective on the regulation of m6A modification in tumors.

Indexed as

Epithelial to mesenchymal transitionHNRNPCN6-methylationNSCLCTFAP2A

Identifiers

PMID40057699
PMCPMC11889907

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.