Evidence map›Paper›PMID 40057554›Full record

ArticleScientific reports2025

Reduced removal of waste products from energy metabolism takes center stage in human brain aging.

Silvia Mangia, Mauro DiNuzzo, Sara Ponticorvo, Gerald A Dienel, Kevin L Behar, Helene Benveniste, Fahmeed Hyder, Federico Giove, Suzana Herculano-Houzel, Ognen A Petroff and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Silvia MangiaDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. mangia@umn.edu.
Mauro DiNuzzoNetabolics SRL, Rome, RM, Italy.
Sara PonticorvoDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.
Gerald A DienelDepartment of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Kevin L BeharDepartment of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA.
Helene BenvenisteDepartment of Anesthesiology, Yale University, New Haven, CT, USA.
Fahmeed HyderDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Federico GioveCentro Ricerche Enrico Fermi, Rome, RM, Italy.
Suzana Herculano-HouzelDepartment of Psychology, Vanderbilt University, Nashville, TN, USA.
Ognen A PetroffDepartment of Neurology, Yale University, School of Medicine, New Haven, CT, USA.
Lynn E EberlyDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.
Pavel FilipDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.
Shalom MichaeliDepartment of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA.
Douglas L RothmanDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Mehmet Akcakaya · 2019 to 2026
$11.7M
Obtaining brain pCO2, pH and pO2 maps via measurements of neurovascular coupling: a novel non-invasive approach to identify the culprits of loss of brain functionDP1AG093028 · NIA · UNIVERSITY OF MINNESOTA · PI Silvia Mangia · 2024 to 2026
$3.2M
13C MRS Studies of Brain Mitochondrial Metabolism in Insulin ResistanceR01NS087568 · NINDS · YALE UNIVERSITY · PI PETERSEN, KITT F, ROTHMAN, DOUGLAS LYLE · 2014 to 2018
$2.1M
Homeostatic modeling of functional neuroimaging data in humans: a novel methodology to obtain brain maps of tissue pCO2, pO2 and pH in agingR01AG087526 · NIA · UNIVERSITY OF MINNESOTA · PI Silvia Mangia, Douglas Lyle Rothman · 2024 to 2026
$2.0M
Validation of GABA MRS as a Biomarker of InhibitionR01MH109159 · NIMH · YALE UNIVERSITY · PI BEHAR, KEVIN L, ROTHMAN, DOUGLAS LYLE · 2016 to 2019
$1.7M
MRS validation of computational metabolic modeling of human brain function to determine energetic disruptions underlying fMRI-derived functional connectivity in degenerative or psychiatric disordersR01NS100106 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2017 to 2021
$959k
Metabolic and neuromodulatory basis of altered activated and deactivated cortical areas in healthy human agingR56AG079086 · NIA · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED, ROTHMAN, DOUGLAS LYLE · 2022 to 2022
$657k
NIA NIH HHS DP1 AG093028NIA NIH HHS R01 AG087526NIA NIH HHS R56 AG079086NIBIB NIH HHS P41 EB027061NIH HHS P41 EB027061NIH HHS R01 AG087526NIMH NIH HHS R01 MH109159NINDS NIH HHS R01 NS087568NINDS NIH HHS R01 NS100106
6 · The paper itself

Abstract

Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO

Indexed as

AgingBrainEnergy MetabolismAdultAgedCarbon DioxideCerebrovascular CirculationFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedOxygen ConsumptionPositron-Emission TomographyYoung AdultCarbon Dioxide

Identifiers

PMID40057554
PMCPMC11890754

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.