Evidence map›Paper›PMID 40057522›Full record

ArticleNature communications2025

Gout management using uricase and sodium citrate hollow mesoporous nanomotors.

Lu Liu, Xiurong Li, Yongxian Chen, Junbin Gao, Yuejun Jiang, Yicheng Ye, Peng Wang, Fei Peng, Yingfeng Tu

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lu Liu *Pharmacy Department, The Fifth Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Xiurong Li *NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Yongxian Chen *Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Junbin GaoNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Yuejun JiangNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Yicheng YeNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Peng WangPharmacy Department, The Fifth Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China. 13688860780@163.com.ORCID http://orcid.org/0009-0006-9038-9516
Fei PengSchool of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou, China. pengf26@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-8817-3472
Yingfeng TuNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. tuyingfeng1@smu.edu.cn.ORCID http://orcid.org/0000-0003-2605-0172

Funding

China Postdoctoral Science Foundation 2023M741595National Natural Science Foundation of China (National Science Foundation of China) 22175083National Natural Science Foundation of China (National Science Foundation of China) 22405119National Natural Science Foundation of China (National Science Foundation of China) 51973241; 22375224
6 · The paper itself

Abstract

Uricase (UOx)-based gout treatments are generally limited due in part to the accumulation of H

Indexed as

GoutNanoparticlesSodium CitrateUrate OxidaseAnimalsCell SurvivalHumansHydrogen PeroxideMaleMicePorositySilicon DioxideUric AcidHydrogen PeroxideSilicon DioxideSodium CitrateUrate OxidaseUric Acid

Identifiers

PMID40057522
PMCPMC11890746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.