Evidence map›Paper›PMID 40057496›Full record

ArticleNature communications2025

Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells.

Hongxian Zhu, Andrew M Sydor, Bing-Ru Yan, Ren Li, Michal T Boniecki, Carina Lyons, Miroslaw Cygler, Aleixo M Muise, Michelle E Maxson, Sergio Grinstein and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongxian ZhuCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-7370-4226
Andrew M SydorCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3585-0446
Bing-Ru YanCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-2138-7374
Ren LiCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
Michal T BonieckiDepartment of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.ORCID http://orcid.org/0000-0002-0854-0891
Carina LyonsCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.
Miroslaw CyglerDepartment of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada.ORCID http://orcid.org/0000-0003-4579-1881
Aleixo M MuiseCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-9624-3346
Michelle E MaxsonCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-1493-490X
Sergio GrinsteinCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0795-4160
Brian RaughtPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
John H BrumellCell Biology Program, Hospital for Sick Children, Toronto, ON, Canada. john.brumell@sickkids.ca.ORCID http://orcid.org/0000-0002-5802-7789

Funding

COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8M
Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseRC2DK122532 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KLEIN, CHRISTOPH, MUISE, ALEIXO M · 2020 to 2024
$9.1M
Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) FDN#143202Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) FDN#154329Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) FDN#408445Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT#156093Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) RGPIN#04330NIDDK NIH HHS RC2 DK118640NIDDK NIH HHS RC2 DK122532U.S. Department of Health & Human Services | National Institutes of Health (NIH) RC2DK118640U.S. Department of Health & Human Services | National Institutes of Health (NIH) RC2DK122532
6 · The paper itself

Abstract

Salmonella utilizes type 3 secreted effector proteins to induce plasma membrane (PM) perturbations during invasion of host cells

Indexed as

Cell MembraneLeucine-Rich Repeat Serine-Threonine Protein Kinase-2SalmonellaSalmonella InfectionsSalmonella typhimuriumAnimalsBacterial ProteinsHEK293 CellsHeLa CellsHost-Pathogen InteractionsHumansPhosphorylationrab GTP-Binding ProteinsVacuolesBacterial ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanRab10 protein, humanrab GTP-Binding Proteins

Identifiers

PMID40057496
PMCPMC11890592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.