Evidence map›Paper›PMID 40057493›Full record

ArticleCell death & disease2025

Oncogenic and microenvironmental signals drive cell type specific apoptosis resistance in juvenile myelomonocytic leukemia.

Naile Koleci, Ying Wu, Niels Anton Wehner, Jovana Rajak, Venugopal Rao Mittapalli, Julia Mergner, Hui Xiao, Jun Wang, Madeleine Wahl, Sheila Bohler and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Naile KoleciDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Ying WuDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-6095-1524
Niels Anton WehnerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jovana RajakDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Venugopal Rao MittapalliDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Julia MergnerBavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0002-4332-1280
Hui XiaoDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jun WangDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Madeleine WahlDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sheila BohlerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-8860-9424
Konrad AumannDepartment of Pathology, Institute for Clinical Pathology, University Medical Center Freiburg, Freiburg, Germany.
Georg HäckerInstitute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-1058-5746
Senthilkumar RamamoorthyDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Melanie BoerriesInstitute of Medical Bioinformatics and Systems Medicine, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-3670-0602
Susanne KirschnekInstitute for Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-7771-7817
Miriam ErlacherDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. miriam.erlacher@uniklinik-ulm.de.ORCID http://orcid.org/0000-0002-7261-1447

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) TRR 353/1 - 471011418
6 · The paper itself

Abstract

Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signaling and characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using MxCre;Ptpn11

Indexed as

ApoptosisLeukemia, Myelomonocytic, JuvenileTumor MicroenvironmentAnimalsbcl-X ProteinHumansMiceMonocytesMyeloid Cell Leukemia Sequence 1 ProteinProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-bcl-2ras ProteinsSignal Transductionbcl-X ProteinMyeloid Cell Leukemia Sequence 1 ProteinProtein Tyrosine Phosphatase, Non-Receptor Type 11Proto-Oncogene Proteins c-bcl-2ras Proteins

Identifiers

PMID40057493
PMCPMC11890777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.