ArticleNature communications2025
Reduced temporal and spatial stability of neural activity patterns predict cognitive control deficits in children with ADHD.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study.bioRxiv : the preprint server for biology · 2026Article
- Dissociable Patterns of Atypical Error Monitoring in Developmental Dyslexia and Attention Deficit Hyperactivity Disorder.Brain sciences · 2026Article
- Multicenter randomized trial of a digital therapeutic game for executive function in children with ADHD.NPJ digital medicine · 2026Article
- Dynamic modeling in neurocognitive frameworks of childhood ADHD: a review of inhibitory control and reward systems.Translational psychiatry · 2026Review
- The Impact of ADHD on Children's Language Development.Children (Basel, Switzerland) · 2026Review
- Inhibited oligodendrogenesis impairs attention and motivation in adult mice regardless of repeated mild traumatic brain injury.Frontiers in behavioral neuroscience · 2026Article
- Time-resolved aperiodic dynamics in event segmentation in attention-deficit/hyperactivity disorder.Brain communications · 2026Article
- Working memory capacity and emotion regulation strategies differentially predict proactive and reactive cognitive control.Frontiers in psychology · 2026Article
- Cognitive Control Decision-Making Dynamics Across Internalizing and Externalizing Symptoms in Youth.Research on child and adolescent psychopathology · 2025Article
- Exploring the neural basis of reaction time variability in ADHD: The importance of examining data at the trial level.Neuroimage. Reports · 2025Article
- Maternal Immune Activation and Neurodevelopmental Disorders: Integrating Molecular, Cellular and Systems Mechanisms.Neuropsychiatric disease and treatment · 2025Review
- Verbal fluency tasks and attention problems in children with ADHD: evidence from fNIRS.Frontiers in neurology · 2025Article
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7 authors.
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Abstract
This study investigates the neural underpinnings of cognitive control deficits in attention-deficit/hyperactivity disorder (ADHD), focusing on trial-level variability of neural coding. Using fMRI, we apply a computational approach to single-trial neural decoding on a cued stop-signal task, probing proactive and reactive control within the dual control model. Reactive control involves suppressing an automatic response when interference is detected, and proactive control involves implementing preparatory strategies based on prior information. In contrast to typically developing children (TD), children with ADHD show disrupted neural coding during both proactive and reactive control, characterized by increased temporal variability and diminished spatial stability in neural responses in salience and frontal-parietal network regions. This variability correlates with fluctuating task performance and ADHD symptoms. Additionally, children with ADHD exhibit more heterogeneous neural response patterns across individuals compared to TD children. Our findings underscore the significance of modeling trial-wise neural variability in understanding cognitive control deficits in ADHD.
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