Evidence map›Paper›PMID 40056908›Full record

Trial reportCell reports. Medicine2025

A circadian and app-based personalized lighting intervention for the reduction of cancer-related fatigue.

Caleb Mayer, Olivia Walch, Walter Dempsey, Kevin Hannay, Caroline Clingan, Zoe Bowen, Michelle Rozwadowski, Zachery R Reichert, N Lynn Henry, Joshi J Alumkal and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04827446 (A Randomized Trial Of The SYNC APP), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04827446 nacompletednot on this map

A Randomized Trial Of The SYNC APP

TypeinterventionalSponsorUniversity of Michigan Rogel Cancer CenterRan2021 to 2023Enrolled139ConditionsBreast Cancer, Prostate Cancer, Hematologic Malignancy, SurvivorshipArmsWearable Sensor, Blue-blocking glasses, Clear glasses, Full SYNC app, "Dummy" SYNC app
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caleb MayerDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Olivia WalchArcascope, Arlington, VA 22203, USA; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
Walter DempseyDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA; Institute for Social Research, University of Michigan, Ann Arbor, MI 48109, USA; Center for Methodologies for Adapting and Personalizing Prevention, Treatment, and Recovery Services for SUD and HIV (MAPS Center), University of Michigan, Ann Arbor, MI 48109, USA.
Kevin HannayDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA; Arcascope, Arlington, VA 22203, USA.
Caroline ClinganDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Zoe BowenDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Michelle RozwadowskiDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Zachery R ReichertDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
N Lynn HenryDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Joshi J AlumkalDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Muneesh TewariDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel B ForgerDepartment of Mathematics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Institute for Data Science, University of Michigan, Ann Arbor, MI 48109, USA.
Sung Won ChoiDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sungchoi@med.umich.edu.

Funding

Patient-Oriented Research and Mentoring in Hematopoietic Cell TransplantationK24HL156896 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUNG WON CHOI · 2021 to 2026
$870k
NHLBI NIH HHS K24 HL156896
6 · The paper itself

Abstract

Lighting interventions can mitigate fatigue by promoting circadian rhythmicity. We test whether individualized, wearable-based lighting interventions delivered via a mobile app reduce cancer-related fatigue in a randomized controlled trial with 138 breast cancer, prostate cancer, and hematopoietic stem cell transplant patients. Participants are randomized to tailored lighting intervention or control. The primary endpoint is PROMIS fatigue 4a at trial end, with secondary endpoints including change in daily fatigue, sleep, anxiety, depression, physical function, and overall health. Fatigue T-scores at week 11 do not differ between groups but decrease significantly from week 1 to week 11 (3.07 points, p = 0.001) in the intervention group, with a significant final-week treatment effect (p = 0.014). Daily fatigue, anxiety, sleep disturbance, and physical function improve within intervention. Further studies are needed to see if these results generalize in broader cancer care. The trial is registered at ClinicalTrials.gov (trial registration number: NCT04827446).

Indexed as

Circadian RhythmFatigueLightingMobile ApplicationsNeoplasmsAdultAgedBreast NeoplasmsFemaleHumansMaleMiddle AgedPrecision Medicinecancercancer-related fatiguecircadian rhythmlighting interventionsmathematical modelspersonalized medicineprecision medicinewearable devices

Identifiers

PMID40056908
PMCPMC11970396

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.