Evidence map›Paper›PMID 40056905›Full record

ArticleCell reports. Medicine2025

TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units.

Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue, Nicholas Legere, Albert S Yu, Fahad Shah, Adrianna Perez, Zhu Li, Evan Jellison and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pengyu ZongCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, 337 Mansfield Road, Unit 1272, Storrs, CT 06269, USA. Electronic address: zong@uchc.edu.
Cindy LiCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, 337 Mansfield Road, Unit 1272, Storrs, CT 06269, USA.
Jianlin FengCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA.
Zhichao YueCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA.
Nicholas LegereCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
Albert S YuCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA.
Fahad ShahCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA.
Adrianna PerezCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA.
Zhu LiDepartment of Immunology, University of Connecticut School of Medicine (UConn Health), Farmington, 263 Farmington Avenue, CT 06030, USA.
Evan JellisonDepartment of Immunology, University of Connecticut School of Medicine (UConn Health), Farmington, 263 Farmington Avenue, CT 06030, USA.
Yasuo MoriLaboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Barbara MillerDepartments of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, PA 17033, USA.
Rajkumar VermaDepartment of Neuroscience, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA.
Bruce LiangCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA.
Lixia YueCalhoun Cardiology Center, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Cell Biology, University of Connecticut School of Medicine (UConn Health), 263 Farmington Avenue, Farmington, CT 06030, USA. Electronic address: lyue@uchc.edu.

Funding

Calcium Signaling Mechanisms in Cardiac FibrogenesisR01HL171486 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Lixia Yue · 2024 to 2026
$2.0M
Transient Receptor Potential Melastatin 2 (TRPM2) in Ischemic StrokeR01NS131661 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Lixia Yue · 2024 to 2026
$1.3M
NHLBI NIH HHS R01 HL171486NINDS NIH HHS R01 NS131661
6 · The paper itself

Abstract

Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death. We reveal that TRPM2 expression in human peripheral leukocytes strongly correlates with plasma lipid levels. In middle-aged Apoe

Indexed as

HyperlipidemiasMyeloid CellsTRPM Cation ChannelsAnimalsApolipoproteins EDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedApolipoproteins ETRPM2 protein, humanTRPM2 protein, mouseTRPM Cation ChannelsBBBblood-brain-barrier damageendothelial dysfunctionhyperlipidemiamyeloid cell activationoxLDLstrokeTRPM2

Identifiers

PMID40056905
PMCPMC11970404

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.