Evidence map›Paper›PMID 40056755›Full record

ArticleSchizophrenia research2025

Implementing early psychosis services: Experiences from the laboratory for early psychosis center.

Jacqueline F Dow, Nicole Cerundolo, Katerina Konstas, Emily E Carol, Kelsey A Johnson, Matcheri S Keshavan, Dost Öngür

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07713849 (Adapting and Improving Transition Care for First Episode Psychosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07713849 recruitingnot on this mapstarted 2026, after this paper: background citation

Adapting and Improving Transition Care for First Episode Psychosis

Typeobservational_patient_registrySponsorUniversity of ChicagoRan2026 to 2029Enrolled75ConditionsSchizoaffective Disorders, Bipolar Disorder With Psychotic Features, Schizophrenia Disorders, Major Depressive Disorder With Psychotic FeaturesArmsTransition Care Team
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacqueline F DowDivision of Psychotic Disorders, McLean Hospital, 115 Mill St., Belmont, MA 02478, USA. Electronic address: jdow@mclean.harvard.edu.
Nicole CerundoloDivision of Psychotic Disorders, McLean Hospital, 115 Mill St., Belmont, MA 02478, USA. Electronic address: ncerundolo@mgh.harvard.edu.
Katerina KonstasDivision of Psychotic Disorders, McLean Hospital, 115 Mill St., Belmont, MA 02478, USA. Electronic address: kkonstas@mgb.org.
Emily E CarolDivision of Psychotic Disorders, McLean Hospital, 115 Mill St., Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 22 Shattuck St., Boston, MA 02115, USA. Electronic address: ecarol@mgb.org.
Kelsey A JohnsonDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Massachusetts Mental Health Center, Boston, MA 02115, USA. Electronic address: kjohns20@bidmc.harvard.edu.
Matcheri S KeshavanDepartment of Psychiatry, Harvard Medical School, 22 Shattuck St., Boston, MA 02115, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA; Massachusetts Mental Health Center, Boston, MA 02115, USA. Electronic address: mkeshava@bidmc.harvard.edu.
Dost ÖngürDivision of Psychotic Disorders, McLean Hospital, 115 Mill St., Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, 22 Shattuck St., Boston, MA 02115, USA. Electronic address: dongur@mgb.org.

Funding

Randomized controlled trial of enhanced coordinated specialty care (CSC 2.0)P50MH115846 · NIMH · MCLEAN HOSPITAL · PI Dost Ongur · 2019 to 2026
$16.9M
NIMH NIH HHS P50 MH115846
6 · The paper itself

Abstract

Increased research on early psychosis treatment and clinical outcomes has prompted interest in greater understanding of the efficacy of coordinated specialty care (CSC) across the United States. CSC clinics have become the standard for early psychosis care and act as a venue through which learning health systems (LHS) can be established. A learning health system integrates research findings into clinical care to create a continuous feedback loop. The Laboratory for Early Psychosis (LEAP) Center's position as a part of a learning health system in Massachusetts serves to improve care across the state through ongoing research on the effectiveness of early psychosis interventions. The following report highlights the LEAP Center's foundation as an LHS, as well as the systems and relationships that contribute to the success of learning health systems. Recommendations and practical applications are explored for interested stakeholders to implement an LHS that best serves their populations.

Indexed as

Early Medical InterventionMental Health ServicesPsychotic DisordersHumansMassachusettsCoordinated specialty careEarly psychosisEPINETFirst-episode psychosisLearning health system

Identifiers

PMID40056755
PMCPMC11957919

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.