Evidence map›Paper›PMID 40056419›Full record

ArticleCell reports2025

Podoplanin-positive cell-derived small extracellular vesicles contribute to cardiac amyloidosis after myocardial infarction.

Maria Cimini, Ulrich H E Hansmann, Carolina Gonzalez, Andrew D Chesney, May M Truongcao, Erhe Gao, Tao Wang, Rajika Roy, Elvira Forte, Vandana Mallaredy and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Maria CiminiAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Ulrich H E HansmannDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019-5251, USA.
Carolina GonzalezAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Andrew D ChesneyDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019-5251, USA.
May M TruongcaoAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Erhe GaoAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Tao WangAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Rajika RoyDepartment of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Elvira ForteThe Jackson Laboratory, Bar Harbor, ME, USA.
Vandana MallaredyAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Charan ThejAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Ajit MagadumAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Darukeshwara JoladarashiAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Cindy BenedictAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Water J KochDepartment of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Çağla TükelCenter for Microbiology & Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Raj KishoreAging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA; Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA. Electronic address: raj.kishore@temple.edu.

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Walter J. Koch · 2017 to 2026
$21.0M
Targeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2020 to 2024
$11.4M
Role of ZBP1 in pathogenesis of Salmonella biofilmsR01AI171568 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI SIDDHARTH BALACHANDRAN, Cagla Tukel · 2023 to 2026
$3.4M
The role of bacterial amyloid curli in Alzheimer's DiseaseR01AI153325 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2024
$2.4M
Restoration of myocardial reparative function of diabetic progenitor cells by epigenetic modulationR01HL143892 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2020 to 2023
$2.2M
MyomiR-499, Exosomes and Endothelial and Endothelial Progenitor Cells dysfunction in DiabetesR01HL169405 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2024 to 2026
$1.8M
Structural Transitions in Proteins and Protein AssembliesR01GM120634 · NIGMS · UNIVERSITY OF OKLAHOMA · PI HANSMANN, ULRICH H.E. · 2017 to 2020
$1.2M
NHLBI NIH HHS P01 HL134608NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL143892NHLBI NIH HHS R01 HL169405NIAID NIH HHS R01 AI153325NIAID NIH HHS R01 AI171568NIGMS NIH HHS R01 GM120634
6 · The paper itself

Abstract

Cardiac amyloidosis is a secondary phenomenon of an already pre-existing chronic condition. Whether cardiac amyloidosis represents one of the complications post myocardial infarction (MI) has yet to be fully understood. Here, we show that amyloidosis occurs after MI and that amyloid fibers are composed of macrophage-derived serum amyloid A 3 (SAA3) monomers. SAA3 overproduction in macrophages is triggered by exosomal communication from cardiac stromal cells (CSCs), which, in response to MI, activate the expression of a platelet aggregation-inducing type I transmembrane glycoprotein, Podoplanin (PDPN). CSC

Indexed as

AmyloidosisExtracellular VesiclesMembrane GlycoproteinsMyocardial InfarctionAnimalsHumansMacrophagesMaleMiceMice, Inbred C57BLMyocardiumPodoplaninSerum Amyloid A ProteinStromal CellsMembrane GlycoproteinsPDPN protein, humanPdpn protein, mousePodoplaninSaa3 protein, mouseSerum Amyloid A Proteincardiac amyloidosisCP: Cell biologyCP: Metabolismmyocardial infarctionPodoplaninretro-inverso D-peptideserum amyloid A 3Toll-like receptor 2

Identifiers

PMID40056419
PMCPMC12019684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.