Evidence map›Paper›PMID 40056312›Full record

ArticleSleep & breathing = Schlaf & Atmung2025

Association between periventricular white matter hyperintensity and moderate-to-severe patients with sleep apnea syndrome.

Masahiro Uchimura, Fusao Ikawa, Toshikazu Hidaka, Shingo Matsuda, Mizuki Kambara, Seiji Tamaya, Tetsuo Betsuyaku, Nobutaka Horie, Yasuhiko Akiyama, Kentaro Hayashi

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Masahiro UchimuraDepartment of Neurosurgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.
Fusao IkawaDepartment of Neurosurgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan. fikawa-nsu@umin.ac.jp.ORCID 0000-0003-4205-1490
Toshikazu HidakaDepartment of Neurosurgery, Shimane Prefectural Central Hospital, Izumo, Shimane, Japan.
Shingo MatsudaDepartment of Neurosurgery, JA Hiroshima General Hospital, Hatsukaichi, Hiroshima, Japan.
Mizuki KambaraDepartment of Neurosurgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.
Seiji TamayaTokyo Angel Hospital, Hachioji, Tokyo, Japan.
Tetsuo BetsuyakuTokyo Angel Hospital, Hachioji, Tokyo, Japan.
Nobutaka HorieDepartment of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yasuhiko AkiyamaDepartment of Neurosurgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.
Kentaro HayashiDepartment of Neurosurgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

Funding

Japan Society for the Promotion of Science 23K08521
6 · The paper itself

Abstract

purposeThe association between sleep apnea syndrome (SAS) severity and white matter hyperintensities (WMHs) has been previously described. However, the associated anatomical details of WMHs remain unclear. The WMHs were divided into periventricular hyperintensity (PVH) and deep and subcortical white matter hyperintensity (DWMH). PVH is characterized as a non-vascular entity, whereas DWMH is vascular in nature. This study aimed to clarify the association between SAS and the anatomical details of WMHs.

methodsPatients (n = 237) diagnosed with neurologically asymptomatic SAS (1999-2016) were enrolled. Any symptomatic SAS patients, whose MRI was conducted more than six months prior to SAS diagnosis, or whose data were incomplete were excluded. For patients with multiple MRI scans, the most recent imaging was employed. SAS diagnosis was defined as an apnea-hypopnea index (AHI) ≥ 5. PVH and DWMH were graded from 0 to IV according to severity. Age, sex, medical history, body mass index, AHI, estimated duration of SAS, and MRI findings were collected. Factors associated with PVH and DWMH grade ≥ I were analyzed.

resultsPVH grade ≥ I was associated with the estimated duration of SAS (odds ratio, 1.01; 95% confidence interval, 1.00-1.02), DWMH grade ≥ I (102.04; 21.40-486.49), hypertension (4.05; 1.53-10.74), and cerebral atrophy (17.47; 1.36-225.28). Age (1.07; 1.03-1.12) and PVH grade ≥ I (88.73; 19.07-412.86) were significantly associated with DWMH grade ≥ I.

conclusionThis study confirmed that PVH rather than DWMH is associated with SAS. This study may contribute to research on the mechanism of WMHs caused by SAS.

Indexed as

Sleep Apnea SyndromesWhite MatterAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSeverity of Illness IndexApnea–hypopnea indexDeep and subcortical white matter hyperintensityPeriventricular hyperintensityPeriventricular white matter high intensitySleep apnea syndrome

Identifiers

PMID40056312

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.