ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
Determinants of time to positivity in bloodstream infections: an analysis of a population-based cohort in Queensland, Australia.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Risk Factors of Blood Culture Positivity and Mortality in Bloodstream Infections: A Population-Based Study of Patients With B-Cell Malignancies.European journal of haematology · 2026Article
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Abstract
purposeTime to Positivity (TTP) measures the interval from incubation to bacterial growth detection in blood cultures. Although shorter TTP is associated with higher mortality, factors associated with TTP remain uncertain.
methodsA retrospective cohort study was conducted among Queensland residents with positive blood cultures between 2000-2019. Incident bloodstream infections (BSIs) were identified using Pathology Queensland data, with demographic, clinical, and outcome data linked to state-wide databases.
resultsThe study analysed 84,341 patients with monomicrobial BSI with a median patient age of 65.6 years (IQR 45.4-78.1), and most infections being community-associated (77.0%). Age showed a non-linear relationship with TTP, and male sex was linked with slightly higher TTP (Incidence Rate Ratio (IRR) 1.01; 95% Confidence Intervals (CI) 1.00-1.02; p = 0.011), reflecting a small but measurable association. Liver disease and malignancy were associated with lower TTP (IRR 0.93; 95% CI 0.91-0.95; p < 0.0001 and IRR 0.95; 95% CI 0.94-0.97; p < 0.0001 respectively), whilst diabetes showed no significant difference (IRR 1.01; 95% CI 1.00-1.02; p = 0.0840). Hospital onset infections exhibited longer TTPs (IRR 1.09; 95% CI 1.08-1.10; p < 0.0001).
conclusionsThere are several host characteristics associated with TTP that may in part explain the complex relationship between this variable and mortality. Beyond microbiological factors such as isolate type, TTP is also influenced by clinical variables including patient demographics and infection characteristics highlighting its potential as a prognostic marker. Further evaluation is needed to clarify its role in predicting patient outcomes and guiding tailored treatment strategies.
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