Evidence map›Paper›PMID 40056300›Full record

ArticleDigestive diseases and sciences2025

It's a Women's World: A New Look at Sex Differences in Patients with the Irritable Bowel Syndrome.

Madison R Heath, Zlatan Mujagic, Yuying Luo, Daniel Keszthelyi

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In one paragraph

Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Madison R HeathDepartment of Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zlatan MujagicDepartment of Gastroenterology-Hepatology, Maastricht University Medical Center+, PO Box 5800, 6202AZ, Maastricht, The Netherlands. z.mujagic@maastrichtuniversity.nl.
Yuying LuoMount Sinai Center for Gastrointestinal Physiology and Motility, Mount Sinai West & Morningside, New York, NY, USA.
Daniel KeszthelyiDepartment of Gastroenterology-Hepatology, Maastricht University Medical Center+, PO Box 5800, 6202AZ, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) exhibits significant sex differences. The female predominance in its worldwide prevalence and variations in symptomatology, treatment efficacy, and adverse effects all may arise from differences in pathophysiology. Due to entrenched historical biases, only recently have studies considered biological differences between the sexes that could affect the understanding of IBS. In this commentary, inspired by a study published in the Digestive Diseases and Sciences, the authors not only focus on different aspects of sexual dimorphism in IBS but also elaborate on the challenges that arise from studying female physiology and its temporal changes in relation to disease characteristics and treatment outcomes.

Indexed as

Irritable Bowel SyndromeSex CharacteristicsFemaleHumansMalePrevalenceSex FactorsGut microbiotaIrritable bowel syndromeProinflammatory cytokinesSex differencesSex hormones

Identifiers

PMID40056300

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.