Evidence map›Paper›PMID 40056223›Full record

ArticleActa neurochirurgica2025

Mental fatigue and cognitive functioning in patients presenting with non-enhancing gliomas.

Alice Neimantaite, Tomás Gómez Vecchio, Isabelle Rydén, Dima Harba, Asgeir S Jakola, Anja Smits

Abstract read
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In one paragraph

Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alice NeimantaiteDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. alice.neimantaite@neuro.gu.se.ORCID 0009-0004-0293-6707
Tomás Gómez VecchioDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Isabelle RydénDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Dima HarbaDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Asgeir S JakolaDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anja SmitsDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

ALF ALFGBG-965033ALF ALFGBG-965622Vetenskapsrådet 2017-00944
6 · The paper itself

Abstract

purposePatients with diffuse lower-grade gliomas (LGG) often suffer from mental fatigue. In healthy subjects, mental fatigue has a negative impact on cognitive functioning. This relation may be more complex in LGG, where tumor localization and growth rate also impact brain function. Our aim was to investigate how self- and observer-reported variables of mental fatigue and cognitive functioning were connected before tumor treatment.

methodsConsecutive patients scheduled for surgery due to presumed LGG were screened (n = 157). LGG was presumed if the mass was suggestive of diffuse glioma, but without significant contrast enhancement. Isocitrate dehydrogenase (IDH)-mutated WHO grade 2 or 3 gliomas (the LGG group) were analyzed separately. We included 101 patients in the entire cohort, whereas 71 patients constituted the LGG group. Patient data included: (1) self-reported assessments of mental fatigue and cognitive functioning, (2) neuropsychological test performances, and (3) clinical/demographic characteristics. Spearman's partial correlations were calculated between the variables and visualized in a correlation network.

resultsCognitive impairment was self-reported by 50% of the entire cohort and 45% of the LGG group, while observer-evaluated testing showed cognitive impairment in 40% and 34% of the cases respectively. Self-reported assessments showed no correlations (≥ 0.3 or ≤-0.3) with neuropsychological test performances. A consistent correlation was seen between self-reported mental fatigue and self-reported cognitive functioning (entire cohort: rho=-0.66, LGG group: -0.64).

conclusionOur results highlight the complexity of evaluating symptoms of mental fatigue and cognitive functioning even prior to surgery. Self-reports and neuropsychological testing were weakly correlated, hence these should be handled complimentary.

Indexed as

Brain NeoplasmsCognitionCognitive DysfunctionGliomaMental FatigueAdultAgedFemaleHumansMaleMiddle AgedNeuropsychological TestsSelf ReportCognitionGliomaMental fatigueNeuropsychological testsSelf reports

Identifiers

PMID40056223
PMCPMC11890337

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.