Evidence map›Paper›PMID 40056220›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

A questionnaire-based cross-sectional survey of cutaneous adverse events in cancer patients treated with molecular targeted therapy and immunotherapies.

Shan He, Fanping Yang, Lichen Tang, Jin Yang, Shengan Chen, Zihua Chen, Lanting Wang, Zhen Zhang, Li Ma, Xiaoqun Luo

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Shan He *Department of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Fanping Yang *Department of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Lichen TangFudan University Shanghai Cancer Center, Shanghai, China.
Jin YangDepartment of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Shengan ChenDepartment of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Zihua ChenDepartment of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Lanting WangDepartment of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Zhen ZhangDepartment of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Li MaDepartment of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China.
Xiaoqun LuoDepartment of Allergy & Immunology, Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China. luoxiaoqun913@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvances in anticancer treatments have significantly improved disease control and progression-free survival. These therapies are associated with various adverse events (AEs), especially cutaneous toxicities. However, there is a paucity of patient-reported outcomes on cutaneous AEs (CAEs) and associated alternation of quality of life (QoL) in cancer patients.

objectiveTo evaluate the impact of CAEs on QoL and related social factors in cancer patients.

methodsA cross-sectional questionnaire-based study was conducted in Huashan Hospital affiliated with Fudan University, Fudan University Shanghai Cancer Center, and Zhongshan Hospital affiliated with Fudan University. This study utilized a patient-based questionnaire including social factors, skincare routines, incidence of CAEs, and the impact on QoL.

resultsOf the 1004 survey participants, 599 reported suffering from CAEs after targeted therapies. The majority of participants were female. Breast cancer was the most frequently reported cancer type. Itching was the most frequently reported problem, followed by eczema, hair loss, hand-foot reaction syndrome, and dry skin. Female participants had significantly lower DLQI scores than males. The need for multidisciplinary approaches in managing skin adverse events was emphasized by 78.30% of participants.

conclusionPatient self-report is critical to early detection and proper management for CAEs in cancer patients receiving novel anticancer therapies, thus improving patients' prognosis and QoL. Furthermore, our study emphasized the importance of closer collaboration between dermatologists and oncologists.

Indexed as

Antineoplastic AgentsDrug EruptionsImmunotherapyMolecular Targeted TherapyNeoplasmsAdultAgedAged, 80 and overChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresQuality of LifeAntineoplastic AgentsAnticancer therapiesCutaneous adverse reactionsQuality of lifeQuestionnaire-based study

Identifiers

PMID40056220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.