Evidence map›Paper›PMID 40056216›Full record

ArticleArchives of dermatological research2025

DNA methylation-based analysis of leukocyte landscape in children with atopic dermatitis.

Richie Jeremian, Kaiyang Li, Melissa Galati, Melinda Gooderham, Cathryn Sibbald, Yuka Asai, Vincent Piguet, Carolyn S Jack

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Richie JeremianMcGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, 1001 Bd Décarie, Montréal, Québec, H4A 3J1, Canada. richie.jeremian@mail.mcgill.ca.
Kaiyang LiMcGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, 1001 Bd Décarie, Montréal, Québec, H4A 3J1, Canada.
Melissa GalatiTemerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Melinda GooderhamSKiN Centre for Dermatology, Peterborough, Ontario, Canada.
Cathryn SibbaldDivision of Dermatology, Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Yuka AsaiDivision of Dermatology, School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.
Vincent PiguetDivision of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Carolyn S JackMcGill University Health Centre (MUHC) Center of Excellence for Atopic Dermatitis, 1001 Bd Décarie, Montréal, Québec, H4A 3J1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) is the most common chronic, inflammatory skin condition among the pediatric population. There is a need to better characterize the leukocytic landscape of AD for disease stratification, surveillance, and to identify therapeutic targets. We utilized a novel DNA methylation (DNAm)-based algorithm to study a publicly available, epigenome-wide DNAm dataset of pediatric AD patients and healthy subjects. In this pediatric cohort, AD was associated with significantly lower estimated proportions of memory B, memory CD4 T, naïve CD4 T, naïve CD8 T, and NK cells, but higher proportions of eosinophils and Tregs. Patients with lower IgE (< 500 IU/mL) had lower abundance of naïve B cells and higher abundance of eosinophils. Males had higher eosinophil abundance than female patients. This study corroborates existing on data on leukocytic populations in AD and demonstrates a scalable method for leukocyte quantification, that may be expanded to allow for better correlation to clinical presentation.

Indexed as

Dermatitis, AtopicDNA MethylationLeukocytesAdolescentAlgorithmsChildChild, PreschoolEosinophilsFemaleHumansImmunoglobulin EInfantMaleImmunoglobulin EAtopic dermatitisDNA-methylationEpigeneticsLeukocytes

Identifiers

PMID40056216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.