Evidence map›Paper›PMID 40056213›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Long-term outcomes of Yttrium-90 transarterial radioembolization for patients with hepatocellular carcinoma.

Riccardo Muglia, Massimo De Giorgio, Paolo Marra, Francesco Saverio Carbone, Ludovico Dulcetta, Carolina Prussia, Alessandro Loglio, Arianna Ghirardi, Laura Antra Grikke, Claudia Bianchi and 6 more

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Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The predictive value ofEuropean journal of nuclear medicine and molecular imaging · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Riccardo Muglia *Radiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy. rmuglia@asst-pg23.it.ORCID 0000-0003-0092-5065
Massimo De Giorgio *Gastroenterology Hepatology & Transplantation Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Paolo MarraRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Francesco Saverio CarboneRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Ludovico DulcettaRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Carolina PrussiaSchool of Medicine, University of Milano-Bicocca, Milano, Italy.
Alessandro LoglioGastroenterology Hepatology & Transplantation Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Arianna GhirardiFondazione per la Ricerca Ospedale di Bergamo (FROM) Ente del Terzo Settore (ETS), Bergamo, Italy.
Laura Antra GrikkeEast Clinical University Hospital, Riga, Latvia.
Claudia BianchiMedical Physics Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Gian Luca PoliMedical Physics Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Alberto GeraliNuclear Medicine Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Paola Anna ErbaSchool of Medicine, University of Milano-Bicocca, Milano, Italy.
Sandro SironiRadiology Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Stefano FagiuoliGastroenterology Hepatology & Transplantation Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.
Mauro ViganòGastroenterology Hepatology & Transplantation Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe retrospectively assessed the long-term outcomes of Yttrium-90 (

methodsWe included patients with HCC treated with

resultsAmong 142 patients (median age 66.8, cirrhotic 92.3%; M: F = 121:21), a median OS of 16.68 months was achieved, with a complete radiological response in 31% (44/142). OS was strongly correlated with radiological response (p < 0.001). Absorbed dose ≥ 234.6 Gy was associated with complete response (p = 0.017) but not with survival (p = 0.102). Rising alpha-fetoprotein levels (p = 0.017) and worsening Child-Pugh scores post-TARE (p = 0.044) were independent predictors of mortality.

conclusionA complete radiological response is crucial for long-term survival, highlighting the need for dosimetry optimization in TARE for HCC.

Indexed as

Carcinoma, HepatocellularEmbolization, TherapeuticLiver NeoplasmsYttrium RadioisotopesAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeYttrium-90Yttrium RadioisotopesAlpha-fetoproteinHepatocellular carcinomaOverall survivalRadiological responseTransarterial radioembolization

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.