SynthesisOrthopadie (Heidelberg, Germany)2025
[Treatment of rotator cuff lesions using autologous conditioned plasma-a systematic review].
Synthesis in Orthopadie (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
2 authors.
Funding
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Abstract
backgroundTendinopathies and rotator cuff tears account for significant medical costs in Germany and are driven by degenerative collagen changes. Despite multiple treatment options, no standard exists. This study examines PRP's growing use for pain relief and tissue healing in chronic tendinopathies.
objectiveEffect of subacromial PRP-injections on VAS pain in patients with chronic tendinopathies and partial ruptures of the rotator cuff.
methodsA systematic review was conducted using PubMed, Livivo, Google Scholar, and Cochrane Library. Only randomized controlled trials published up to September 2024 were included; they were evaluated per PRISMA guidelines (2020) and the Cochrane Risk of Bias Tool.
resultSeven RCTs (n = 612 patients) examined PRP injections for rotator cuff pathologies, comparing them to controls receiving saline (n = 1), physiotherapy (n = 2), hyaluronic acid/combo injections (n = 1), cortisone (n = 2), or prolotherapy/corticosteroid/lidocaine (n = 1). The PRP group showed a significant VAS pain reduction in the 3‑month follow-up compared to the baseline measurement. The intergroup comparison revealed heterogeneous patterns of significance.
conclusionThis study provides moderate evidence that PRP may be preferred over other interventions, but may be effective as an additional treatment option. However, further high-quality single intervention placebo-control studies with a larger number of participants are needed to validate this result.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.