ReviewArchives of toxicology2025
Exploiting TRP channel diversity in insects: a pathway to next-generation pest management.
Review in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Multimodal targets of (-)-α-thujone mediating avoidance behavior of a stored-products pest, Tribolium castaneum, in response to irritant stimuli.Pest management science · 2026Article
- Integrative screening of plant volatiles through transient receptor potential channel docking, olfactometry, and field validation in Bemisia tabaci.Pest management science · 2026Article
- The double-edged sword of ion channel-targeting pesticides: a paradigm shift from health risks to precision intervention.Archives of toxicology · 2026Review
- A Thermo-Sensitive Molecular Switch:International journal of molecular sciences · 2026Article
- Decoding thermal adaptation: genome-wide identification of TRP channel repertoire in cephalopods and gene expression responses to chronic thermal exposure inFrontiers in physiology · 2026Article
- Cold-Sensing TRP Channels and Temperature Preference Modulate Ovarian Development in the Model OrganismInternational journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient Receptor Potential (TRP) channels, a diverse family of over 30 ion channel subtypes, are pivotal in regulating sensory perception, thermoregulation, and feeding in insects. In Drosophila melanogaster, 13 TRP channels have been identified, while Aedes aegypti and Anopheles gambiae possess 11 and 10, respectively, showcasing evolutionary adaptations to their ecological niches. This review explores recent advancements in understanding the structure, classification, and physiological functions of TRP channels, emphasizing their evolutionary divergence across Diptera, Lepidoptera, and Hymenoptera. Key TRP subfamilies, such as TRPA, TRPC, TRPM, TRPV, TRPN, and TRPP, are discussed, highlighting their roles in chemo-sensation, gustation, and stress responses. Examples include TRPA1's involvement in thermal sensing and TRPV's role in osmoregulation, critical for insect survival under fluctuating environmental conditions. The review highlights the potential of TRP channels as targets for pest control, focusing on TRP-specific insecticides like pymetrozine, afidopyrifen, and flonicamid, which impact feeding and sensory pathways. RNA interference (RNAi) techniques targeting TRP genes are highlighted as promising tools for innovative pest management. TRP channels' role in mediating thermal tolerance is particularly significant in the context of climate change, where variable temperatures challenge pest dynamics and agricultural sustainability. Understanding these mechanisms is vital for developing climate-resilient pest control strategies. The review also evaluates methodologies used in TRP channel studies, including genomic, transcriptomic, and functional assays, alongside behavioural analyses. Despite progress, challenges remain in studying TRP channels in non-model insects and elucidating their regulation. Future research should integrate multidisciplinary approaches to fully harness TRP channels for sustainable pest management.
Indexed as
Identifiers
40056168What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.