Evidence map›Paper›PMID 40056166›Full record

ArticleArchives of dermatological research2025

PeiTuQingXin formula alleviated atopic dermatitis symptoms via inhibiting TRADD/TRAF2/RIP1 complex mediated NF-κB signaling pathway activation.

Zixuan Cheng, Xin Ma, Feng Luo, Xiumei Mo, Junfeng Liu, Dachan Chen, Fenggen Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zixuan ChengThe Second Clinical School of Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Xin MaThe Second Clinical School of Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Feng LuoThe Second Clinical School of Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
Xiumei MoState Key Laboratory of Dampness Syndrome of Chinese Medicine, Department of Dermatology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Junfeng LiuState Key Laboratory of Dampness Syndrome of Chinese Medicine, Department of Dermatology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Dachan ChenState Key Laboratory of Dampness Syndrome of Chinese Medicine, Department of Dermatology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. cdc@gzucm.edu.cn.
Fenggen YanState Key Laboratory of Dampness Syndrome of Chinese Medicine, Department of Dermatology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. fenggen_yan@gzucm.edu.cn.

Funding

Chen Da-Chan famous Medical studio project of Guangdong Provincial Hospital of Traditional Chinese Medicine NO.Y0096Guangdong-Hong Kong-Macau Joint Laboratory on Chinese Medicine and Immune Disease Research 2020B1212030006Guangdong Provincial Key Laboratory of Chinese Medicine for Preventions and Treatment of Refractory Chronic Diseases 2018B030322012;MB2020KF04Guangzhou Basic and Applied Basic Research Foundation 2023A03J0747; 2023B03J0562Key-Area Research and Development Program of Guangdong Province 2020B1111100010Municipal schools jointly funded projects 2024A03J0544National Administration of Traditional Chinese Medicine Inheritance and innovation "hundred and ten million" talent project (Qihuang project) Qihuang scholar project [2018] No. 284State Key Laboratory of Dampness Syndrome of Chinese Medicine SZ2021ZZ17;SZ2021ZZ39
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease with recurrent course, and traditional Chinese medicine (TCM) is regarded as an effective treatment. In this study, we aim to evaluate the potential effects and elucidate the mechanism of PTQX formula in alleviating a house dust mite (HDM)-induced AD model. NC/Nga mice were divided into Control, AD model and PTQX-treated and stimulated with HDM oinment. PTQX formula exerted significant anti-inflammatory effects, alleviated dermatitis performance, decreased the serum IgE by more than 2-fold, reduced the secretion level of other inflammatory cytokines and downregulated the Th2 cells ratio in lymph nodes. Treatment with PTQX formula reduced the level of inflammatory cytokines, which was measured by an inflammatory cytokine array kit (RayBio

Indexed as

Anti-Inflammatory AgentsDermatitis, AtopicDrugs, Chinese HerbalAnimalsCytokinesDisease Models, AnimalFemaleHumansImmunoglobulin EMaleMiceNF-kappa BPyroglyphidaeSignal TransductionTh2 CellsTNF Receptor-Associated Factor 2Anti-Inflammatory AgentsCytokinesDrugs, Chinese HerbalImmunoglobulin ENF-kappa BTNF Receptor-Associated Factor 2TRAF2 protein, mouseAtopic dermatitisNF-κB signaling pathwayPeiTuQingXin (PTQX) formulaTRADD

Identifiers

PMID40056166
PMCPMC11890400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.