Evidence map›Paper›PMID 40056057›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Real-Time Cell Death Self-Reporting Theranostic Agent for Dynamic Optimization of Photodynamic Therapy.

Wei Bian, Qiyue Wang, Cui He, Pan Tao, Juanjuan Zheng, Yulu Zhang, Jing Li, Fangyuan Li, Hongyan Jia, Daishun Ling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wei BianDepartment of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Qiyue WangFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Cui HeKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, 030000, China.
Pan TaoFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Juanjuan ZhengFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yulu ZhangKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, 030000, China.
Jing LiDepartment of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Fangyuan LiDepartment of Clinical Laboratory, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Hongyan JiaDepartment of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Daishun LingFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID https://orcid.org/0000-0002-9977-0237

Funding

Central Government Guides Local Funds for Science and Technology Development YDZJSX2024C028Central Government Guides Local Funds for Science and Technology Development YDZJSX2024D068Fundamental Research Funds for the Central Universities 23X010301599Fundamental Research Funds for the Central Universities 24X010301678Fundamental Research Funds for the Central Universities YG2023ZD03National Natural Science Foundation of China 32422045Natural Science Foundation of Shanxi Province 201901D111210Natural Science Foundation of Shanxi Province 202203021221186Science and Technology Innovation Plan Of Shanghai Science and Technology Commission 22TS1400700Shanghai Municipal Key Discipline of Health System 2024ZDXK0065Shanxi Province Higher Education "Billion Project" Science and Technology Guidance Project BYJL025
6 · The paper itself

Abstract

The therapeutic efficiency of photodynamic therapy (PDT) hinges on the drug-light interval (DLI), yet conventional approaches relying on photosensitizer accumulation often lead to suboptimal irradiation and adverse side effects. Here, a real-time cell death self-reporting photodynamic theranostic nanoagent (CDPN) is presented that dynamically monitors extracellular potassium ion ([K⁺]

Indexed as

Breast NeoplasmsPhotochemotherapyPhotosensitizing AgentsTheranostic NanomedicineAnimalsApoptosisCell DeathCell Line, TumorFemaleHumansMiceNanoparticlesPotassiumPhotosensitizing AgentsPotassiumfluorescence imagingimaging‐guided surgerynanosensorphotodynamic therapytheranostic agent

Identifiers

PMID40056057
PMCPMC12061277

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.