Evidence map›Paper›PMID 40056046›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Enhancing Osteogenesis through Bio-Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production.

Fei Yu, Xing Zhao, Ting Jiang, Ningjuan Ouyang, Peilin Li, Wei Yang, Zhihe Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fei YuState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Xing ZhaoDepartment of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, 610041, China.
Ting JiangDepartment of Pediatric Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Ningjuan OuyangDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Peilin LiState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Wei YangCollege of Polymer Science and Engineering, Med-X Center for Materials, Sichuan University, Chengdu, 610065, China.
Zhihe ZhaoState Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.ORCID https://orcid.org/0000-0003-2955-1706

Funding

China Postdoctoral Science Foundation 2023M742491IOF Research Grant IOF2022Y01Med-X Innovation Programme of Med-X Center for Materials of Sichuan University MCM202305National Natural Science Foundation of China 32271416National Natural Science Foundation of China 52125301National Natural Science Foundation of China 62306193National Natural Science Foundation of China 82401169Natural Science Foundation of Sichuan Province 2023NSFSC0562Natural Science Foundation of Sichuan Province 2023NSFSC1584Sichuan University Postdoctoral Interdisciplinary Innovation Fund JCXK2202West China School/ Hospital of Stomatology, Sichuan University RCDWJS2022-1
6 · The paper itself

Abstract

Bio-inspired coral-derived scaffolds have been adopted for bone regeneration. However, these confront challenges such as the limited osteoinductive properties, environmental concerns, and ambiguous calcification mechanisms in coral proteins. In this study, the role of the recombinant coral protein galaxin in promoting osteogenesis is investigated. The observations reveal that recombinant galaxin regulates the mitochondrial metabolism in mouse pre-osteoblasts by interacting with the β subunit of ATP synthase. This ultimately promotes osteogenesis of pre-osteoblasts. Furthermore, galaxin is integrated with gelatin methacryloyl (GelMA) and assess the osteogenic potential of the resulting galaxin-GelMA composites in mouse mandibular defects. The observations emphasize the distinctive role of galaxin in regulating mitochondrial functionality and osteogenesis. Additionally, these provide prospective insights for further applications of bio-inspired recombinant coral proteins in regenerative medicine.

Indexed as

Adenosine TriphosphateAnthozoaMitochondriaOsteogenesisAnimalsBone RegenerationMiceOsteoblastsRecombinant ProteinsAdenosine TriphosphateRecombinant Proteinsbio‐inspiredbone regenerationcoralgalaxinmitochondrial metabolism

Identifiers

PMID40056046
PMCPMC12061279

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.