ArticleJournal of the American Heart Association2025
Impact of Vascular Geometry on Thrombosis in Pediatric Patients With Modified Blalock-Taussig-Thomas Shunt: A Pilot Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Computational fluid dynamics-based risk stratification of modified Blalock-Taussig-Thomas shunt thrombogenicity.The Journal of thoracic and cardiovascular surgery · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundThrombosis in modified Blalock-Taussig-Thomas shunts (mBTTS) poses a life-threatening risk for infants with shunt-dependent congenital heart disease. Although hemodynamics influence thrombosis, the specific geometric contributors remain unclear. This study aimed to identify key variables to inform future hemodynamic analysis, hypothesizing that brachiocephalic, subclavian artery, mBTTS, and/or pulmonary artery (PA) geometry play a critical role in clot formation. METHODS AND
resultsWe retrospectively analyzed 11 infants with hypoplastic left heart syndrome who underwent mBTTS placement. Using computed tomography and magnetic resonance imaging, we generated 3-dimensional models of the shunt and surrounding vasculature. Geometric variables related to shunt positioning and vascular insertion were measured and compared between patients with (n=5) and without (n=6) thrombotic occlusions. Significant differences in vascular geometry were observed between occluded and nonoccluded shunts. Occluded shunts had longer PA lengths (12.4 mm versus 8.4 mm,
conclusionsSignificant geometric differences in the PA, brachiocephalic, and subclavian arteries were associated with mBTTS thrombosis, supporting the hypothesis that vascular geometry plays a critical role in clot formation. These findings provide a foundation for future hemodynamic analyses and may inform surgical planning to reduce thrombosis risk in patients with mBTTSs.
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