Structural Insights into 4,5-DOPA Extradiol Dioxygenase from

Chih-Chia Chiang, Yen-Ju Lu, Jia-Wei Liu, Sheng-Wei Lin, Chun-Chi Chou, Chia-Hsin Lin, I-Weh Chien, Chun-Hua Hsu

Abstract read

In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Multiple transitions to high l-DOPA 4,5-dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales.The New phytologist · 2025
Article
In planta complementation of the betalain biosynthetic pathway with a bacterial dioxygenase.PloS one · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chih-Chia ChiangDepartment of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.

Yen-Ju LuDepartment of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.

Jia-Wei LiuDepartment of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.

Sheng-Wei LinInstitute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.

Chun-Chi ChouDepartment of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.

Chia-Hsin LinInstitute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.

I-Weh ChienDepartment of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.

Chun-Hua HsuDepartment of Agricultural Chemistry, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0002-0008-7383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Betalains, a group of pigments widely distributed in various plants, are extensively applied in the food, beverage, and medicinal industries. The biosynthesis of betalains involves the enzymatic action of 4,5-DOPA-dioxygenase, which catalyzes the key ring-opening reaction of DOPA to produce betalamic acid, a crucial intermediate in the pathway. The crystal structure of a 4,5-DOPA-dioxygenase from

Indexed as

BetalainsBeta vulgarisOxygenasesPlant ProteinsAmino Acid SequenceCatalytic DomainMolecular Docking SimulationProtein ConformationSubstrate SpecificityBetalainsextradiol dioxygenaseOxygenasesPlant Proteinsbetalainsbetalamic acidcrystal structureextradiol dioxygenase

Identifiers

PMID40055856

DOI10.1021/acs.jafc.4c09501

PMCPMC11926856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.