ArticleJournal of animal science and biotechnology2025
Gut microbiota-mediated bile acid transformations regulate the transport of aflatoxin B1 from the intestine to the liver in piglets.
Article in Journal of animal science and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Porcine intestinal goblet cells: Guardians of mucosal immunity and barrier function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Review
- Host-Microbiota Interactions in the Regulation of Intestinal Health in Weaned Piglets: Molecular Mechanisms and Nutritional Intervention Strategies.Animals : an open access journal from MDPI · 2026Review
- Polysaccharides-gut microbiota interaction: mechanisms regulating the hepatocellular carcinoma immune microenvironment.Frontiers in immunology · 2026Review
- Microbiome-mycotoxin interactions and probiotic strategies: implications for gut health and cancer.Frontiers in nutrition · 2026Review
- Advances in understanding the role of gut microbiota in fat deposition and lipid metabolism.Journal of animal science and biotechnology · 2025Review
- Taurochenodeoxycholic acid promotes abdominal fat deposition by modulating the crosstalk between bile acid metabolism and intestinal microbiota in broilers.Journal of animal science and biotechnology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAflatoxins have been reported as a significant pollutant in feed, capable of causing harm to the liver, gastrointestinal tract and kidneys of piglets. However, research on the interactions among aflatoxin B1 (AFB1), bile acid (BA) metabolism and gut microbiota is limited.
methodsIn this study, piglets were treated with AFB1 and antibiotics (ABX) to evaluate the interaction between AFB1 and gut microbiota. Subsequently, the roles of the farnesoid X receptor (FXR) and sterol 12α-hydroxylase (CYP8B1) in AFB1 absorption were studied by using FXR agonists obeticholic acid (OCA) and Cyp8b1-knockout (KO) mice, respectively.
resultAFB1 inhibited bile salt hydrolase (BSH) activity in ileal microbiota, downregulated ileal FXR expression, and upregulated CYP8B1 expression in liver, increasing the proportion of 12α-OH BAs and potentially enhancing AFB1 absorption. ABX treatment reduced AFB1 absorption and liver damage, and unexpectedly increased BSH activity, counteracting the AFB1-induced downregulation of FXR and upregulation of CYP8B1. OCA reactivated ileal FXR, reduced AFB1 absorption, and alleviated liver damage. Furthermore, Cyp8b1-KO mice showed increased resistance to AFB1-induced liver damage by lowering AFB1 absorption.
conclusionsThese results underscore the significance of gut microbiota and BAs in AFB1 absorption, suggesting new strategies to mitigate health risks from AFB1 in piglets.
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