Evidence map›Paper›PMID 40055771›Full record

ArticleWorld journal of emergency surgery : WJES2025

Role of the admission muscle injury indicators in early coagulopathy, inflammation and acute kidney injury in patients with severe multiple injuries.

Liuquan Mu, Haideng Song, Mengdi Jin, Kaige Li, Yushan Guo, Nan Jiang

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In one paragraph

Article in World journal of emergency surgery : WJES, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Macrophages on demand: How tissue trauma shapes their role.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Liuquan Mu *Department of Trauma Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Haideng Song *Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Mengdi JinDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China.
Kaige LiDepartment of Trauma Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Yushan GuoDepartment of Trauma Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Nan JiangDepartment of Trauma Center, China-Japan Union Hospital of Jilin University, Changchun, 130033, China. jiangn@jlu.edu.cn.

Funding

Jilin Provincial Department of Science and Technology Project YDZJ202202CXJD043Project of Jilin Provincial Department of Finance 2020SCZ30
6 · The paper itself

Abstract

backgroundsCoagulopathy, inflammation and organ failure are common complications in trauma patients. This study aimed to explore the possible role of muscle injury indicators in early coagulopathy, systemic inflammatory response syndrome (SIRS), and acute kidney injury (AKI) in patients with severe multiple trauma.

methodsA retrospective analysis was performed using trauma center patient data from 2020 to 2023. The incidence of coagulopathy, SIRS and AKI in patients with multiple injuries were assessed. The relationship between Myoglobin, creatine kinase (CK), lactate dehydrogenase (LDH) and trauma severity was investigated, and the influence of these three muscle injury indicators on patient adverse outcomes was analyzed.

resultsA total of 312 patients with severe multiple injuries were included in this study, with an average age of 51.7 and a median Injury Severity Score (ISS) of 22.5. Among them, 115 patients developed coagulopathy, 169 patients developed SIRS, 26 patients developed AKI, and 11 patients died during hospitalization. We found that Myoglobin (r = 0.225, P < 0.001), CK (r = 0.204, P < 0.001), LDH (r = 0.175, P = 0.002) were positively correlated with ISS. Myoglobin is an independent risk factor for coagulopathy (OR = 1.90, 95%CI: 1.45-2.49), SIRS (OR = 1.41, 95%CI: 1.10-1.79), and AKI (OR = 4.17, 95%CI: 2.19-7.95). CK is an independent risk factor for coagulopathy (OR = 1.30, 95%CI: 1.00-1.67), while LDH is an independent risk factor for SIRS (OR = 1.49, 95%CI: 1.17-1.89) and AKI (OR = 2.30, 95%CI: 1.43-3.69). Especially for AKI, Myoglobin had a good predictive effect (AUC = 0.804, 95%CI:0.716-0.891). The best cut-off value is when the Myoglobin value is 931.11 µg/L, at which point the sensitivity is 61.53% and the specificity is 87.41%.

conclusionsThe admission muscle injury index can predict trauma complications such as AKI, early coagulation disease, and SIRS, especially AKI. Compared to CK and LDH, admission myoglobin can predict complications remarkably, even better than ISS, especially AKI. Routine testing of muscle injury indicators upon admission is meaningful and can help physicians identify and prevent the occurrence of complications.

Indexed as

Acute Kidney InjuryBlood Coagulation DisordersMultiple TraumaAdultAgedBiomarkersCreatine KinaseFemaleHumansInflammationInjury Severity ScoreL-Lactate DehydrogenaseMaleMiddle AgedMyoglobinRetrospective StudiesBiomarkersCreatine KinaseL-Lactate DehydrogenaseMyoglobinAKICoagulopathyMultiple injuriesMuscle injury indicatorsMyoglobinSIRS

Identifiers

PMID40055771
PMCPMC11887167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.