Evidence map›Paper›PMID 40055766›Full record

ReviewStem cell research & therapy2025

Human dental pulp stem cells for spinal cord injury.

Kaizhong Wang, Xiangyan Liu, Xukai Jiang, Shuang Chen, Hui Wang, Zhenbo Wang, Qiwen Wang, Zhonghai Li

Abstract readReview
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaizhong Wang *Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
Xiangyan Liu *Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
Xukai JiangDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
Shuang ChenDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
Hui WangDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
Zhenbo WangDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
Qiwen WangDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China.
Zhonghai LiDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, 116011, China. lizhonghaispine@126.com.ORCID http://orcid.org/0000-0003-4735-1193

Funding

the Dalian Medical Science Research Program 2023DF009the Medical-Industrial Joint Innovation Funding Project of First Hospital of Dalian Medical University and Dalian Institute of Chemical Physics DMU-1&DICP UN202311the Science and Technology Innovation Foundation of Dalian 2022JJ12SN045
6 · The paper itself

Abstract

Spinal cord injury (SCI) is a serious neurological disorder that causes loss of mobility, pain, and autonomic dysfunction, resulting in altered sensation and devastating loss of function. Current treatments for SCI mainly focus on surgery and drug therapy to promote neurological recovery. However, there are virtually no effective remedies for irreversible nerve damage that result in a victim's loss of motor function and sensory changes that occur after an injury. With the continuous development of medical technology, stem-cell-based regenerative medicine provides researchers with new treatment ideas. The effectiveness of mesenchymal stem cells and their derivatives from different sources in treating SCI varies. Recent studies have highlighted that dental pulp stem cells (DPSCs) may contribute to anti-inflammatory regulation, anti-apoptotic regulation, and axonal regeneration in the treatment of SCI patients. In addition, the combination of new biomaterials and dental pulp stem cells is promising in the treatment of SCI. This article reviews the role of DPSCs in SCI treatment in recent years, discusses the advantages of DPSCs, explores potential development directions, and looks forward to providing new insights for future research in this critical field.

Indexed as

Dental PulpSpinal Cord InjuriesStem CellsStem Cell TransplantationAnimalsHumansMesenchymal Stem CellsApoptosisAxonal regenerationDental pulp stem cellsInflammatoryNeurorestorationSpinal cord injuryStem cells

Identifiers

PMID40055766
PMCPMC11887269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.