Evidence map›Paper›PMID 40055733›Full record

Trial reportWorld journal of surgical oncology2025

Effect of superficial cervical plexus nerve block with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patients undergoing radical thyroid cancer surgery under general anesthesia: a prospective randomized controlled trial.

Xiaoyu Kang, Caifen Li, Liuyu Lu, Xiaotong Qin, Yonghao Wang, Yang Lu, Li Ma, Shaoliang Zhu, Zheng Gong

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effect of Bilateral Superficial Cervical Plexus Block on Postoperative Pain in Thyroid and Parathyroid Surgery: A Systemic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Pooled it
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoyu Kang *Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China.
Caifen Li *Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China.
Liuyu LuDepartment of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China.
Xiaotong QinDepartment of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China.
Yonghao WangDepartment of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China.
Yang LuDepartment of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China.
Li MaDepartment of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China.
Shaoliang ZhuDepartment of Hepatobiliary, Pancreas and Spleen Surgery, The People'S Hospital of Guangxi Zhuang Autonomous Region, Nanning, P.R. China. slzhu2014@163.com.
Zheng GongDepartment of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Qingxiu District, 6 Taoyuan Road, Nanning, Guangxi, 530021, P.R. China. GZqyydoctor@163.com.

Funding

Guangxi Medical and Health Appropriate Technology Development and Application of the Project No. S2022008Guangxi Science and Technology Department, Guangxi Natural Science Foundation Project No. 2023GXNSFAA026324Guangxi Science and Technology Department, Guangxi Nature Fund Key Project No. 2024GXNSFDA999033Guangxi Traditional Chinese Medicine Appropriate Technology Development and Promotion Project No. GZSY22-58Self-financed Scientific Research Project of the Administration of Traditional Chinese Medicine of Guangxi Zhuang Autonomous Region No. GXZYZ20210558Self-financed Scientific Research Project of the Health Commission of Guangxi Zhuang Autonomous Region No. Z20210258
6 · The paper itself

Abstract

objectiveTo investigate the effect of ultrasound-guided bilateral superficial cervical plexus nerve blocks with Ropivacaine or a combination of different adjuvants on perioperative analgesia and quality of postoperative recovery in patients undergoing radical thyroid cancer surgery under general anesthesia with nerve monitoring without muscarinic maintenance.

methodsA total of 140 patients undergoing elective radical thyroid cancer surgery were randomly divided into four groups, with 35 cases in each group: general anesthesia alone group (Group C), general anesthesia + Ropivacaine group (Group R), general anesthesia + Ropivacaine combined with dexmedetomidine group (Group R1), and general anesthesia + Ropivacaine combined with dexamethasone group (Group R2). The primary observation index were postoperative resting and active Visual Analogue Score. The secondary observation index were hemodynamics, intraoperative sedative and analgesic medication use, postoperative analgesic requirements, postoperative recovery indicators, Richards-Campbell Sleep Questionnaire scores, Quality of Postoperative Recovery-15 scores, and adverse reactions.

resultsCompared with group C, the resting and active VAS scores in group R were lower within 12 h after surgery (P < 0.05), the resting and active VAS scores in groups R1 and R2 were lower within 24 h after surgery (P < 0.05). Compared with group R, the VAS scores of patients in groups R1 and R2 were lower within 6 to 24 h after operation (P < 0.05). Compared with group R2, only the sedation score after extubation was higher in R1 group (P < 0.05), and there was no statistical difference in any other aspects (P < 0.05).

conclusionBilateral superficial cervical plexus nerve blocks with Ropivacaine or a combination of different adjuvants are superior to general anesthesia alone in terms of intraoperative hemodynamics, the amount of sedative and analgesic drugs, and analgesic efficacy and quality of recovery in patients undergoing radical thyroid cancer surgery with nerve monitoring without muscarinic maintenance. Ropivacaine combined with an adjuvant has better analgesic effectiveness and quality of recovery than without an adjuvant, and Ropivacaine combined with dexmedetomidine has a better sedation level than dexamethasone.

Indexed as

AnalgesiaAnesthesia, GeneralAnesthetics, LocalCervical Plexus BlockPostoperative PainRopivacaineThyroidectomyThyroid NeoplasmsAdultCervical PlexusDexamethasoneDexmedetomidineFemaleFollow-Up StudiesHumansMaleAnesthetics, LocalDexamethasoneDexmedetomidineRopivacaineDexamethasoneDexmedetomidineRadical thyroid cancer surgeryRopivacaineSuperficial cervical plexus nerve blocks

Identifiers

PMID40055733
PMCPMC11887177

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.