Evidence map›Paper›PMID 40055675›Full record

ArticleJournal of neuroinflammation2025

The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice.

Amrita Rajesh, Joyce Gong, Kyle S Chan, Ritvik Viniak, Steven Droho, David Kachar, Joshua Y Strauss, Andrew L Wang, Jeremy A Lavine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amrita RajeshDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
Joyce GongDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
Kyle S ChanDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
Ritvik ViniakDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
Steven DrohoDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
David KacharDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
Joshua Y StraussDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
Andrew L WangDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA.
Jeremy A LavineDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 240. E. Huron St., McGaw M343, Chicago, IL, 60614, USA. jeremy.lavine@northwestern.edu.ORCID http://orcid.org/0000-0002-0884-1336

Funding

Investigating the function and mechanism of interleukin 7 receptor-expressing pro-angiogenic macrophages during experimental choroidal neovascularizationR01EY034486 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jeremy A Lavine · 2023 to 2026
$1.6M
The role of beta2-adrenergic receptor and interleukin-6 signaling in macrophage-driven choroidal neovascularizationK08EY030923 · NEI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LAVINE, JEREMY A · 2020 to 2024
$972k
Retinal perivascular macrophages: ontology and function during neuroinflammationR01EY036826 · NEI · NORTHWESTERN UNIVERSITY · PI Jeremy A Lavine · 2025 to 2026
$800k
BrightFocus Foundation New Investigator AwardNEI NIH HHS K08 EY030923NEI NIH HHS R01 EY034486NEI NIH HHS R01 EY036826Research to Prevent Blindness Medical Student Eye Research FellowshipResearch to Prevent Blindness Unrestricted Departmental Grant
6 · The paper itself

Abstract

backgroundMyeloid cells are heterogeneous cells that are critical for spontaneous choroidal neovascularization (CNV) in the Vldlr METHODS AND

resultsTo investigate the role of monocytes, we bred Ccr2

conclusionsThese data suggest that monocytes and monocyte-derived macrophages are dispensable, microglia are likely initiators for CNV development, and choroidal macrophages are potential key contributors to CNV growth and/or maintenance in the Vldlr

Indexed as

Choroidal NeovascularizationMyeloid CellsReceptors, LDLAnimalsMacrophagesMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMonocytesNuclear Receptor Subfamily 4, Group A, Member 1Receptors, CCR2Nr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Receptors, CCR2Receptors, LDLVLDL receptorAngiogenesisChoroidal neovascularizationMacrophageMacular degenerationMicrogliaVldlr

Identifiers

PMID40055675
PMCPMC11889776

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.