ArticleBMC pregnancy and childbirth2025
Effect of SARS-CoV-2 infection on human embryonic development and clinical outcomes: a retrospective cohort study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo investigate the effect of SARS-CoV-2 infection on embryonic development and clinical outcomes.
methodsThis retrospective analysis included 538 couples in December 2022. The couples were divided into two groups (COVID-19 group, n = 157; and non-COVID-19 [control] group, n = 381) according to whether one member of the couple had been infected with SARS-CoV-2 before oocyte retrieval. The general information, fertility rate, embryonic development and clinical outcomes were compared between the groups.
resultsThere were no significant differences in baseline characteristics between the two groups. The rates of fertility, good-quality embryos and blastocyst formation were similar between the two groups. The separate effects of male or female infection on embryonic development were further analyzed. The in vitro fertilization (IVF) fertilization rate was significant lower in the male COVID-19 group than in the control group (OR = 0.630, 95% CI = 0.510-0.776). In addition, the clinical pregnancy and live birth rate was significantly reduced in female patients who infected by SARS-CoV-2 compared to control group (OR = 0.018, 95% CI = 0.057-0.179).
conclusionThis study shows that infection before oocyte retrieval does not have a clear negative effect on embryo outcomes, such as the rates of normal fertilization, good-quality embryos and blastocyst formation. However, infection before oocyte retrieval has negative effects on clinical outcomes in female patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.