ArticleBMC public health2025
Association of COVID-19 infection and COVID-19 vaccination with idiopathic sudden sensorineural hearing loss in Malaysia: a case-control study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Multimodal biomarkers in idiopathic sudden sensorineural hearing loss: integrating immune, vascular, and metabolic perspectives for precision medicine.Frontiers in immunology · 2026Review
- Comparison of the rates of emergent otologic adverse events following mRNA COVID-19 versus influenza vaccination: a matched cohort analysis.Frontiers in neurology · 2025Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies indicated that the SARS-CoV-2 virus and COVID-19 vaccines may contribute to idiopathic sudden sensorineural hearing loss (ISSNHL). This nationwide study sought to evaluate the correlation between COVID-19 infection and vaccination with ISSNHL.
methodsThis case-control study analysed samples from adults aged 18 years and older who visited the otorhinolaryngology department in 32 government hospitals in Malaysia for pure tone audiometry(PTA) between January 25, 2020 and June 30, 2022. Cases comprised patients diagnosed with ISSNHL, while controls consisted of individuals with normal PTA assessments presenting for other otorhinolaryngology-related symptoms during the same period. Patients with known causes of hearing loss were excluded. Cases and controls were matched in a 1:5 ratio based on age (± 5 years) and index date (± 10 days). The study investigated the association between ISSNHL and both COVID-19 vaccination and COVID-19 infection using conditional logistic regression, with statistical significance set at P < 0.05 for two-sided tests.
resultsA total of 187 ISSNHL cases and 935 matched controls were included. The mean (SD) age of participants was 42.4 (12.3) years, and 704 (62.7%) were female. Cases had a higher proportion of COVID-19 infections compared to controls [16 (8.6%) vs 44 (4.7%), P = 0.034], while both groups had similar proportions of COVID-19 vaccination [90 (48.1%) vs 415 (44.5%), P = 0.377]. Individuals who tested positive for COVID-19 had a significantly higher likelihood of developing ISSNHL compared to those without COVID-19 infection at the time of diagnosis (aOR:2.49; 95% CI:1.176 - 5.260; P = 0.017). However, there was no statistically significant association between COVID-19 vaccination and ISSNHL.
conclusionsThis study provides significant insights into the intricate correlation between ISSNHL, COVID-19 infection, and vaccination. The recognized hazard linked to infection emphasizes the significance of monitoring auditory health in COVID-19 patients.
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