Evidence map›Paper›PMID 40055530›Full record

ArticleNPJ precision oncology2025

Role of GPX3+ astrocytes in breast cancer brain metastasis activated by circulating tumor cell exosomes.

Guanghui Huang, Gongwen Xu, Qianqian Cao, Sheng Li, Hao Li, Xiaonan Zhang, Xiaomei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guanghui Huang *Tumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.ORCID http://orcid.org/0000-0002-5450-9545
Gongwen Xu *School of business, Shandong Jianzhu University, Jinan, China.
Qianqian CaoCancer Center, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Sheng LiShandong First Medical University &Shandong Academy of Medical Sciences, Jinan, China.
Hao LiShandong Institute of Industrial Technology, Jinan, China.
Xiaonan ZhangShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Xiaomei LiTumor Research and Therapy Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. xugongwen@sdu.edu.cn.ORCID http://orcid.org/0009-0008-5945-0395

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain metastasis from breast cancer (BMBC) contributes significantly to mortality, yet its mechanisms remain unclear. This study investigates the activation of GPX3+ astrocytes by circulating tumor cell (CTC)-derived exosomes in the metastatic process. Using a mouse model of BMBC, we performed single-cell RNA sequencing (scRNA-seq) and metabolomics to explore the role of GPX3+ astrocytes in the brain microenvironment. We found that CTCs activate these astrocytes, promoting IL-1β production and Th17 cell differentiation, crucial for the formation of the metastatic niche. Conditional knockout of GPX3 reduced brain metastasis and extended survival, highlighting its importance in metastasis. Our findings uncover a novel mechanism by which CTCs activate GPX3+ astrocytes to drive breast cancer brain metastasis, suggesting new therapeutic targets for intervention.

Identifiers

PMID40055530
PMCPMC11889224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.