Evidence map›Paper›PMID 40055491›Full record

ReviewNature reviews. Molecular cell biology2025

CRISPR-Cas applications in agriculture and plant research.

Aytug Tuncel, Changtian Pan, Joshua S Clem, Degao Liu, Yiping Qi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Molecular cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Adaptive Responses of Tropical Crops: A Multi-Scale Omics Integrated Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Virus-induced transgene- and tissue culture-free heritable genome editing in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Advances in CRISPR Plant Applications.International journal of molecular sciences · 2026
    Review
  17. Article
  18. Article
  19. Plants (Basel, Switzerland) · 2026
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aytug Tuncel *Department of Plant Science and Landscape Architecture, University of Maryland, College Park, MD, USA.ORCID http://orcid.org/0000-0002-4666-5679
Changtian Pan *Department of Horticulture, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-5852-059X
Joshua S ClemDepartment of Plant Science and Landscape Architecture, University of Maryland, College Park, MD, USA.
Degao LiuInstitute of Genomics for Crop Abiotic Stress Tolerance, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX, USA.
Yiping QiDepartment of Plant Science and Landscape Architecture, University of Maryland, College Park, MD, USA. yiping@umd.edu.ORCID http://orcid.org/0000-0002-9556-6706

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growing world population and deteriorating climate conditions necessitate the development of new crops with high yields and resilience. CRISPR-Cas-mediated genome engineering presents unparalleled opportunities to engineer crop varieties cheaper, easier and faster than ever. In this Review, we discuss how the CRISPR-Cas toolbox has rapidly expanded from Cas9 and Cas12 to include different Cas orthologues and engineered variants. We present various CRISPR-Cas-based methods, including base editing and prime editing, which are used for precise genome, epigenome and transcriptome engineering, and methods used to deliver the genome editors into plants, such as bacterial-mediated and viral-mediated transformation. We then discuss how promoter editing and chromosome engineering are used in crop breeding for trait engineering and fixation, and important applications of CRISPR-Cas in crop improvement, such as de novo domestication and enhancing tolerance to abiotic stresses. We conclude with discussing future prospects of plant genome engineering.

Indexed as

AgricultureCRISPR-Cas SystemsCrops, AgriculturalGene EditingGenetic EngineeringGenome, PlantPlant BreedingPlants, Genetically Modified

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.