ArticleScientific reports2025
Provision of human ocular tissue for biomedical research: trends, limitations, and potential solutions from an eye bank.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A combined ex vivo fundus imaging-histology protocol for clinicopathological validation of human donor eyes with limited medical history.Scientific reports · 2026Article
- Comparison of Transcript and Protein Abundance in Human Donor Retinas Support Extending Postmortem Interval From 12 to 18 Hours to Expand the Donor Pool for Biomedical Research.Investigative ophthalmology & visual science · 2026Article
- Global challenges for lens and cataract research.Frontiers in ophthalmology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-mortem donor eye tissues are essential for biomedical research. This study analyzes factors affecting donor eye availability for research through a retrospective review of recoveries at a U.S. eye bank between January 1, 2022, and December 31, 2023. Two time parameters were studied: death-to-recovery interval, defined as the time from death to tissue procurement, and post mortem interval (PMI), which accounts for the additional time required to transport tissue back to the laboratory for final preservation. The dataset was further stratified based on donor history for three ocular diseases frequently requested by researchers: age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy. Among the eyes recovered specifically for research, only 32% of tissues met the < 12 h PMI requirement commonly requested by researchers. Further, only 27% of all research tissues meeting the < 12-hour PMI criterion arrived at the eye bank during current research staffing hours (8 AM-4 PM). The peak arrival time for research tissues was between 2 PM and 7 PM. The availability of tissues with PMI < 12 h further decreased for specific disease states. These findings highlight the logistical challenges of procuring donor eye tissues for research, particularly those with low PMIs. Adjustments by eye banks and researchers - such as extending staffing hours and relaxing strict PMI cutoffs - could significantly expand the donor pool for research. For example, if our eye bank extended research staffing by 3 h and researchers increased the allowable PMI to < 16 h, donor eye availability would increase by 223% over the current approach.
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