ArticleScientific reports2025
Correlation of visual acuity changes and optical coherence tomography imaging in patients with central retinal artery occlusion post-arterial thrombolysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Association of cilioretinal artery perfusion length with central visual acuity and vascular circulation in central retinal artery occlusion.International journal of retina and vitreous · 2026Article
- Systemic Inflammation and Structural Retinal Damage on OCT in Acute Non-Arteritic Central Retinal Artery Occlusion-A Retrospective Study.International journal of molecular sciences · 2026Article
- Optical coherence tomography findings in acute central retinal artery occlusion and their association with visual outcomes.International journal of retina and vitreous · 2025Article
- Atrial fibrillation in Retinal Artery Occlusions.Cardiology and cardiovascular medicine · 2025Article
- Early prostaglandin EFrontiers in ophthalmology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This retrospective study investigates the correlation between visual acuity changes and structural modifications observed through optical coherence tomography (OCT) in patients with central retinal artery occlusion (CRAO) treated with urokinase. Conducted at the Neuro-Ophthalmology Center of Xi'an People's Hospital from January 2022 to May 2023, the study included 217 CRAO patients (217 eyes), comprising 157 males and 60 females, aged 18 to 83 years (mean age: 57.8 ± 13.3 years). Key data were collected on visual acuity, ocular motility, and various imaging techniques at admission and post-thrombolysis. Results showed a significant improvement in visual acuity from 2.4 ± 0.5 to 1.9 ± 0.7 (P < 0.001) after treatment. Notably, patients with severe retinal damage had poorer visual recovery compared to those with milder damage. OCT analysis revealed a decrease in macular foveal retinal thickness from 415.5 ± 107.7 μm to 362.1 ± 93.8 μm (P < 0.001). Correlation analysis confirmed an association between visual acuity and retinal thickness (P < 0.001). Inter-observer variability for OCT grading was assessed using Cohen's Kappa, which yielded a Kappa value of 0.873 (P < 0.001). This study underscores the relationship between visual recovery and retinal structural changes in CRAO patients, emphasizing the efficacy of urokinase treatment, particularly in mild to moderate cases, and the need for personalized therapeutic strategies based on condition severity.
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