Evidence map›Paper›PMID 40055420›Full record

ArticleScientific reports2025

Injectable alginate/collagen clindamycin hydrogel for treatment of surgical site infections.

Roy K Park, Sungwoo Kim, Jeonghyun An, Melissa C Lee, Yunzhi Peter Yang, Tulio A Valdez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roy K Park *Department of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Rd, Palo Alto, CA, 94304, USA.
Sungwoo Kim *Department of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA, 94305, USA.
Jeonghyun AnDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Rd, Palo Alto, CA, 94304, USA.
Melissa C LeeDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Rd, Palo Alto, CA, 94304, USA.
Yunzhi Peter YangDepartment of Orthopaedic Surgery, School of Medicine, Stanford University, Stanford, CA, 94305, USA. ypyang@stanford.edu.
Tulio A ValdezDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, 801 Welch Rd, Palo Alto, CA, 94304, USA. tvaldez1@stanford.edu.

Funding

Tissue Engineering Approaches for Improved Treatment of Early Stage Osteonecrosis of the HipR01AR072613 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B, YANG, YUNZHI · 2018 to 2022
$2.2M
Stanford Clinician Scientist Training ProgramR25DC020174 · NIDCD · STANFORD UNIVERSITY · PI Alan Gi-Lun Cheng · 2022 to 2026
$1.8M
Vascularization in bone tissue engineering constructsR01AR074458 · NIAMS · STANFORD UNIVERSITY · PI YANG, YUNZHI · 2019 to 2023
$1.7M
NIAMS NIH HHS R01 AR072613NIAMS NIH HHS R01 AR074458NIAMS NIH HHS R01AR074458NIDCD NIH HHS 5R25DC020174NIDCD NIH HHS R25 DC020174U.S. Department of Defense W81XWH-20-1-0343
6 · The paper itself

Abstract

The current standard treatment for surgical site infections (SSIs) is marked by prolonged courses of antibiotics, which have limitations due to antibiotic resistance, systemic side effects, and poor patient adherence. We developed a novel injectable alginate/collagen clindamycin hydrogel that rapidly solidifies upon injection and allows for initial burst release followed by sustained release to maintain therapeutic levels. The rheological, morphological, and in-vitro release kinetics of the hydrogel were characterized. Furthermore, with an in-vivo murine SSI model incubated with logarithmic growth phase 1 × 10

Indexed as

AlginatesAnti-Bacterial AgentsClindamycinCollagenHydrogelsStaphylococcal InfectionsSurgical Wound InfectionAnimalsDisease Models, AnimalFemaleInjectionsMiceStaphylococcus aureusAlginatesAnti-Bacterial AgentsClindamycinCollagenHydrogelsAntibiotic therapyBacterial infectionImagingInjectable hydrogelSurgical site infection

Identifiers

PMID40055420
PMCPMC11889102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.