Evidence map›Paper›PMID 40055350›Full record

ArticleNature communications2025

Convection enhanced delivery of Rhenium (

Andrew J Brenner, Toral Patel, Ande Bao, William T Phillips, Joel E Michalek, Michael Youssef, Jeffrey S Weinberg, Carlos Kamiya Matsuoka, Marc H Hedrick, Norman LaFrance and 2 more

Abstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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  11. Preclinical Evaluation of Stable Integrin αPharmaceuticals (Basel, Switzerland) · 2025
    Article
  12. Review
  13. Nanomedicine for Glioblastoma Therapy: Novel Insights and Future Perspectives.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew J BrennerMays Cancer Center at UT Health San Antonio, San Antonio, TX, USA. BrennerA@uthscsa.edu.ORCID http://orcid.org/0000-0002-3985-253X
Toral PatelUT Southwestern Medical Center of Dallas, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-8388-8206
Ande BaoCase Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0009-0007-0096-2858
William T PhillipsMays Cancer Center at UT Health San Antonio, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-8248-7817
Joel E MichalekMays Cancer Center at UT Health San Antonio, San Antonio, TX, USA.
Michael YoussefUT Southwestern Medical Center of Dallas, Dallas, TX, USA.
Jeffrey S WeinbergUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5587-6673
Carlos Kamiya MatsuokaUniversity of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-3216-2728
Marc H HedrickPlus Therapeutics, Austin, TX, USA.
Norman LaFrancePlus Therapeutics, Austin, TX, USA.
Melissa MoorePlus Therapeutics, Austin, TX, USA.ORCID http://orcid.org/0009-0009-2679-7437
John R FloydMays Cancer Center at UT Health San Antonio, San Antonio, TX, USA.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Clinical Development of Rhenium Nanoliposomes (RNL186) for GlioblastomaR01CA235800 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BRENNER, ANDREW JACOB · 2019 to 2023
$3.0M
NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA235800U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA054174U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA235800
6 · The paper itself

Abstract

Rhenium (

Indexed as

Brain NeoplasmsGliomaNeoplasm Recurrence, LocalRadioisotopesRheniumAdultAgedConvectionFemaleHumansLiposomesMaleMaximum Tolerated DoseMiddle AgedProgression-Free SurvivalTreatment OutcomeLiposomesRadioisotopesRhenium

Identifiers

PMID40055350
PMCPMC11889265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.