ArticleNature communications2025
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis.
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Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
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Who cites it
14 citing papers in PubMed.
- Helminth proteins recapitulate key structural motifs of MIF to facilitate immunomodulation of host receptors.iScience · 2026Article
- Targeting lipophagy in atherosclerosis: Molecular mechanisms, pathogenesis and therapeutic interventions (Review).Molecular medicine reports · 2026Review
- Unraveling Atherosclerosis through Multi-omics: Systematic Insights into the Unique Applications and Clinical Perspectives.Current atherosclerosis reports · 2026Review
- Identification of shared oxidative stress related hub genes in NAFLD and atherosclerosis using bioinformatics and machine learning.Scientific reports · 2026Article
- Exploring the Chemotactic Effects of MIF on Neutrophils and T Cells and Methods for Selective Receptor Targeting.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The cardiovascular-immune axis: crosstalk and therapy in atherosclerosis, myocarditis and vasculitis.Frontiers in immunology · 2026Review
- Review
- Integrated proteomics and metabolomics analyses reveal potential molecular signatures of rabbit atherosclerotic plaques.International journal of cardiology. Heart & vasculature · 2025Article
- Adipo-Modulation by Turmeric Bioactive Phenolic Components: From Curcuma Plant to Effects.International journal of molecular sciences · 2025Review
- The multifaced role of the macrophage migration inhibitory factor family in organ fibrosis.American journal of physiology. Cell physiology · 2025Review
- Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies.Redox biology · 2024Article
- Article
- Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer.Scientific reports · 2023Article
- Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers.Nanotheranostics · 2023Review
Corrections and comments
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Authors and funding
37 authors.
Omar El Bounkari *Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany. Omar.El_Bounkari@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-3051-2096
Chunfang Zan *Division of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Bishan YangDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Simon EbertDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID http://orcid.org/0009-0004-5776-2089
Jonas WagnerDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Elina BugarDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Naomi KramerDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Priscila BourilhonDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Christos KontosDivision of Peptide Biochemistry, TUM School of Life Sciences, Technische Universität München (TUM), Freising, Germany.
Marlies ZarwelDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Dzmitry SinitskiDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Jelena MilicDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Yvonne JansenInstitute for Cardiovascular Prevention, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Wolfgang E KempfInstitute of Molecular Vascular Medicine, TUM Klinikum, Technische Universität München (TUM), Munich, Germany.
Nadja SachsInstitute of Molecular Vascular Medicine, TUM Klinikum, Technische Universität München (TUM), Munich, Germany.ORCID http://orcid.org/0000-0001-8031-017X
Lars MaegdefesselInstitute of Molecular Vascular Medicine, TUM Klinikum, Technische Universität München (TUM), Munich, Germany.ORCID http://orcid.org/0000-0001-5228-2634
Hao JiSystems Neuroscience Lab, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Ozgun GokceSystems Neuroscience Lab, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Fabien RiolsMetabolomics and Proteomics Core, Helmholtz Zentrum, Neuherberg, Germany.
Mark HaidMetabolomics and Proteomics Core, Helmholtz Zentrum, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6118-1333
Simona GerraDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Adrian HoffmannDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID http://orcid.org/0009-0000-0661-2321
Markus BrandhoferDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-1629-8353
Maida AvdicDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Richard BucalaYale University School of Medicine, New Haven, CT, USA.
Remco T A MegensInstitute for Cardiovascular Prevention, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9871-6696
Nienke WillemsenInstitute for Cardiovascular Prevention, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Denise MessererDepartment of Medicine I, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Christian SchulzDepartment of Medicine I, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-8149-0747
Alexander BarteltInstitute for Cardiovascular Prevention, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7840-3991
Tobias HarmDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Tübingen, Germany.
Dominik RathDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Tübingen, Germany.
Yvonne DöringInstitute for Cardiovascular Prevention, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9307-3396
Meinrad GawazDepartment of Cardiology and Angiology, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-1124-9592
Christian WeberInstitute for Cardiovascular Prevention, LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany.
Aphrodite KapurniotuDivision of Peptide Biochemistry, TUM School of Life Sciences, Technische Universität München (TUM), Freising, Germany.
Jürgen BernhagenDivision of Vascular Biology, Institute for Stroke and Dementia Research (ISD), LMU Klinikum, Ludwig Maximilian University (LMU) Munich, Munich, Germany. juergen.bernhagen@med.uni-muenchen.de.ORCID http://orcid.org/0000-0003-2996-2652
Funding
Defining the Pathogenic Contribution of High Genotypic MIF ExpressionR01AR078334 · NIAMS · YALE UNIVERSITY · PI BUCALA, RICHARD J · 2021 to 2025
$1.8MNIAMS NIH HHS R01 AR078334
Abstract
Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered and cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), a paralog of the cytokine MIF, as an atypical chemokine promoting both atherosclerosis and hepatic lipid accumulation. In hyperlipidemic Apoe
Indexed as
AtherosclerosisChemokinesIntramolecular OxidoreductasesLipogenesisLiverMacrophage Migration-Inhibitory FactorsAnimalsAntigens, Differentiation, B-LymphocyteApolipoproteins EHepatocytesHistocompatibility Antigens Class IIHumansMaleMiceMice, Inbred C57BLMice, KnockoutAntigens, Differentiation, B-LymphocyteApolipoproteins EChemokinesCXCR4 protein, mouseHistocompatibility Antigens Class IIIntramolecular Oxidoreductasesinvariant chainMacrophage Migration-Inhibitory FactorsReceptors, CXCR4
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