Evidence map›Paper›PMID 40055236›Full record

ReviewCell biochemistry and biophysics2025

Heme Unleashed: NLRP12 Orchestrates PANoptosis in a Symphony of Cell Fate.

Naomi Navuluri, Vinod Kumar Yata, Sudharshan Reddy Dachani, Kartik Rachakonda, Narasaiah Kolliputi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Targeting the non-coding RNA-PANoptosis axis: a novel frontier in disease diagnosis and therapy.Apoptosis : an international journal on programmed cell death · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Naomi NavuluriDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Vinod Kumar YataDepartment of Molecular Biology, Central University of Andhrapradesh, Ananthapuramu, Andhrapradesh, India.
Sudharshan Reddy DachaniDepartment of Pharmacology, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Daadmi, Saudi Arabia.
Kartik RachakondaDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Narasaiah KolliputiDivision of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. nkollipu@usf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pattern recognition receptors (PRRs) help protect hosts from pathogens in different ways. They bind to pathogen-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), or other homeostatic irregularities caused by these patterns to activate an immune response against a pathogen. Certain PRRs activate inflammasomes, leading to cell death and the formation of PANoptosomes, a key process in PANoptosis. PRRs help protect against pathogens, however an excessive number can cause harm to the body and even death. The mechanisms of how to control the PRRs remain unknown. Sundaram et al. [1] address this gap by investigating pathways that activate PANoptosomes in infection-mimicking conditions. They found that the sensor NLRP12 activated PANoptosomes causes inflammation in response to infections leading to the hypothesis that targeting the sensor NLRP12 could be a means to stop the harmful effects of excessive PRRs.This discovery suggests that targeting NLRP12 could mitigate the harmful effects of PRR overactivation, offering a potential therapeutic avenue.

Indexed as

HemeAnimalsHumansInflammasomesIntracellular Signaling Peptides and ProteinsReceptors, Pattern RecognitionHemeInflammasomesIntracellular Signaling Peptides and ProteinsNLRP12 protein, humanReceptors, Pattern RecognitionHemeNLRP12NLRP3PANoptosisPANoptosome complexPathogen associated molecular patterns (PAMP)

Identifiers

PMID40055236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.