ArticleAnalytical and bioanalytical chemistry2025
SI-traceable characterisation of the first reference material for nanoparticle number concentration in suspension to support regulatory compliance.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- "Wire-Print" as a New Sample Preparation Procedure for Accurate Morphological and Chemical Analysis of Particles and Flakes With Microscopy and Spectroscopy Methods.Small methods · 2026Article
- Determination of particle size and number concentrations in gold nanoparticle mixtures: an inter-method study using four analytical techniques (DLS, PTA, SEM and spICP-MS).Nanoscale advances · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reference materials (RMs) are increasingly needed to support number-based characterisation of nanomaterials (NM) in a regulatory context for the purpose of method development, validation and measurement quality control. To date, RMs for number concentration in suspension with a directly assigned value that is SI traceable have been rather scarce, being the LGCQC5050 the only material commercialised so far. This could be attributed to the limited availability of metrologically validated measurement methods and stability challenges associated with long-term storage of NM suspensions. This paper describes development and characterisation of the first RM consisting of 30-nm colloidal gold nanoparticles and value assigned for particle number concentration using the dynamic mass flow (DMF) method with single particle ICP-MS (spICP-MS). Special attention is paid to systematic assessment of the DMF method's performance under operating conditions set outside recommendations described in ISO/TS 19590:2024, but that still comply with key requirements of this method (e.g. use of an ICP-MS system in equilibrium, a cooled spray chamber, etc.). The results of such investigations are reported here for the first time. The paper also discusses practical considerations for the production, storage and transport of nano RMs, and provides guidance on best practice for the production and certification of future nano RMs in accordance with ISO 17034:2016.
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