Evidence map›Paper›PMID 40055058›Full record

ArticleJournal of molecular biology2025

5-Methyluridine is Ubiquitous in Pseudomonas aeruginosa tRNA and Modulates Antimicrobial Resistance and Virulence.

Jurairat Chittrakanwong, Ruixi Chen, Junzhou Wu, Michael S Demott, Jingjing Sun, Kamonwan Phatinuwat, Juthamas Jaroensuk, Sopapan Atichartpongkul, Skorn Mongkolsuk, Thomas Begley and 2 more

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In one paragraph

Article in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jurairat ChittrakanwongProgram in Applied Biological Sciences, Chulabhorn Graduate Institute, Bangkok, Thailand.
Ruixi ChenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Junzhou WuAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.
Michael S DemottDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jingjing SunAntimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.
Kamonwan PhatinuwatProgram in Applied Biological Sciences, Chulabhorn Graduate Institute, Bangkok, Thailand.
Juthamas JaroensukProgram in Applied Biological Sciences, Chulabhorn Graduate Institute, Bangkok, Thailand.
Sopapan AtichartpongkulLaboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand.
Skorn MongkolsukLaboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), OPS, MHESI, Bangkok, Thailand.
Thomas BegleyThe RNA Institute and Department of Biological Sciences, University at Albany, Albany, NY, USA.
Peter C DedonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: pcdedon@mit.edu.
Mayuree FuangthongProgram in Applied Biological Sciences, Chulabhorn Graduate Institute, Bangkok, Thailand; Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), OPS, MHESI, Bangkok, Thailand. Electronic address: mayuree@cri.or.th.

Funding

Translational regulation in exposure biology: Xenobiotic-induced reprograming oftRNA modifications and selective translation of codon-biased response genes in rat and humanmodelsR01ES026856 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI Thomas J Begley, Peter C Dedon · 2016 to 2026
$3.9M
Supplement: Epigenetics of the Human Gut MicrobiomeR01ES031576 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ALM, ERIC JOHN, DEDON, PETER C · 2019 to 2023
$1.9M
Translational regulation during cigarette smoking-induced reprogramming of the tRNA epitranscriptome, in vitro and in a mouse smoking modelR01ES031529 · NIEHS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI BEGLEY, THOMAS J · 2020 to 2024
$1.9M
NIEHS NIH HHS R01 ES026856NIEHS NIH HHS R01 ES031529NIEHS NIH HHS R01 ES031576
6 · The paper itself

Abstract

Building on decades of work in characterizing the dozens of RNA modifications in the microbial epitranscriptome, recent advances in analytical technology and genetics have revealed systems-level functions for many tRNA modifications. The tRNA (uracil-5-)-methyltransferase TrmA and its product, 5-methyl uridine (m

Indexed as

Drug Resistance, BacterialPseudomonas aeruginosaRNA, TransferUridineAnimalsAnti-Bacterial AgentsBacterial ProteinsBiofilmsGene Expression Regulation, BacterialMicePseudomonas InfectionsRNA, BacterialtRNA MethyltransferasesVirulenceAnti-Bacterial AgentsBacterial ProteinsRNA, BacterialRNA, TransfertRNA MethyltransferasesUridinecodon usagePseudomonas aeruginosatranslationTrmAtRNA modification

Identifiers

PMID40055058
PMCPMC12162239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.