Trial reportRegional anesthesia and pain medicine2026
Comparison of femoral triangle plus iPACK blocks with femoral triangle block alone for anterior cruciate ligament reconstruction: a randomized controlled clinical trial on postoperative pain and knee function.
Trial report in Regional anesthesia and pain medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05136352 (Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery, the LIGA-PACK Study), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery, the LIGA-PACK Study
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnterior cruciate ligament reconstruction (ACLR) can cause severe postoperative pain. However, consensus regarding the most effective regional analgesia is lacking. We hypothesized that, compared with femoral triangle block (FTB) and local infiltration analgesia, adding an iPACK block would decrease postoperative morphine consumption.
methodsPatients scheduled for ACLR under general anesthesia were randomly allocated to the FTB (n=45) or the FTB+iPACK group (n=45). The primary outcome was the cumulative oral morphine equivalent (OME) consumption during the first two postoperative days. Secondary outcomes were maximum pain scores, opioid adverse effects, and knee functional scores (Knee Injury and Osteoarthritis Outcome (KOOS), International Knee Documentation Committee (IKDC) and Lysholm) 3, 6, and 9 months after surgery.
resultsCompared with FTB, FTB+iPACK resulted in similar OME consumption (median (IQR)=50 (14-103) vs 60 (32-89) mg, respectively; median of the difference (95% CI): 5 (-14, 28) mg, p=0.49). No significant intergroup differences were found in terms of pain scores, opioid-related side effects, or functional knee recovery. Pain and symptoms subscales of KOOS and IKDC at 9 months were higher for patients with an OME consumption <50 mg within the first two postoperative days, but these statistical differences did not reach the minimal clinically important difference.
conclusionsiPACK block has no additional analgesic benefits for primary ACLR in the setting of a multimodal analgesia regimen including FTB and local infiltration analgesia. TRIAL REGISTRATION NUMBER: NCT05136352.
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