Evidence map›Paper›PMID 40054990›Full record

ArticleBMJ global health2025

The burden of acute respiratory infection in children under 5 attributable to economic inequality in low- and middle-income countries.

Hailu Zhu, Ke Huang, Xueyan Han, Zhaoyang Pan, Hanchao Cheng, Qi Wang, Yicong Wang, Wei Sun, Jiarun Mi, Ting Yang and 3 more

Abstract read
In one paragraph

Article in BMJ global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hailu Zhu *School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0009-0009-8066-0175
Ke Huang *National Center for Respiratory Diseases; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
Xueyan HanSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhaoyang PanSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hanchao ChengSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qi WangSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yicong WangSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wei SunSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jiarun MiSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0001-6186-7132
Ting YangNational Center for Respiratory Diseases; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.ORCID http://orcid.org/0000-0002-7027-5179
Tianjia GuanSchool of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China gtj@sph.pumc.edu.cn txue@hsc.pku.edu.cn.
Tao XueInstitute of Reproductive and Child Health / National Health Commission Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics / Ministry of Education Key Laboratory of Epidemiology of Major Diseases (PKU), School of Public Health, Peking University Health Science Centre, Beijing, China gtj@sph.pumc.edu.cn txue@hsc.pku.edu.cn.
Chen WangNational Center for Respiratory Diseases; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQuantifying the disease burden among children that could potentially be reduced through improvements in individual economic status and regional economic equality can greatly benefit policy making and resource allocation. However, such quantification has rarely been done. This study aimed to assess the inequality-related burden of acute respiratory infection (ARI) (the leading cause of child mortality in low- and middle-income countries (LMICs)) among under five children.

methodsThis study integrated the Demographic and Health Survey data from 53 countries and linked individual records to a novel proxy of economic development status, the satellite night-time light (NTL). We assessed the number of children affected by ARI attributable to within-country economic disparities (eg, NTL<the country-specific 90th percentile) or within-country inequality (eg, NTL<the annual country-specific 90th percentile) from 2001 to 2019 in 133 LMICs, based on the exposure-response relationship between NTL and ARI derived from the study participants.

resultsThe odds of experiencing ARI were decreased significantly (3.5% ((95% confidence interval (CI) 1.4% to 4.4%)) for every 10-digit number increase in NTL. The exposure-response function showed constant decreasing in the risk of ARI as NTL level increases. It is estimated that within-country economic disparities contributed to 11.0% (95% CI 6.1% to 15.6%) of all children affected by ARI in 2001, which was decreased to 8.1% (95% CI 4.2% to 11.8%) in 2019. In contrast, the inequality-related burden remained stable. In sub-Saharan Africa, it increased from 4.8% (95% CI 1.7% to 8.0%) in 2001 to 6.8% (95% CI 3.0%-9.8%) in 2019. Eliminating within-country inequality would have avoided 522 136 (95% CI 2 66 760 to 7 57 414) cases of ARI among children across the 133 LMICs in 2019.

conclusionOur study revealed a protective effect of economic status on preventing ARI in children under 5 years of age. The considerable burden of childhood ARI was attributable to the economic inequality in LMICs. Optimising the allocation of economic resources can safeguard child health.

Indexed as

Cost of IllnessDeveloping CountriesHealth Status DisparitiesRespiratory Tract InfectionsAcute DiseaseChild, PreschoolFemaleHealth SurveysHumansInfantMaleSocioeconomic FactorsChild healthCross-sectional surveyEpidemiologyGlobal Health

Identifiers

PMID40054990
PMCPMC11891534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.