Evidence map›Paper›PMID 40054931›Full record

ArticleJACC. Case reports2025

Pulmonary Tumor Thrombotic Microangiopathy: A Rapidly Progressive Form of Pulmonary Hypertension in Cancer Patients.

Hyeon-Ju Ali, Shengjie Cui, Sandeep Sahay, Horiana B Grosu, Michael W Riben, Anita Deswal, Elie Mouhayar, Cezar Iliescu, Abdelrahman Ali, Saadia A Faiz

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyeon-Ju AliDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: hrali@mdanderson.org.
Shengjie CuiDepartment of Pathology and Laboratory Medicine, Northwell Health Lenox Hill Hospital, New York, New York, USA.
Sandeep SahayDivision of Pulmonary, Critical Care & Sleep Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Horiana B GrosuDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Michael W RibenDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Anita DeswalDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Elie MouhayarDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Cezar IliescuDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Abdelrahman AliDepartment of Cardiology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Saadia A FaizDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary hypertension in patients with advanced solid organ tumors may be secondary to a rare diagnosis of pulmonary tumor thrombotic microangiopathy. Current literature is limited to case reports, and there is no consensus on diagnosis and management. This case highlights the importance of a high degree of clinical suspicion and the role of additional work-up for pulmonary tumor thrombotic microangiopathy including fludeoxyglucose-19-positron emission tomography and cytology of pulmonary artery blood sample at the time of right-sided heart catheterization. Future studies are needed to better understand the role of pulmonary vasodilators and targeted therapies, such as platelet-derived growth factor inhibitors, and their impact on the clinical outcomes for patients with poor prognosis secondary to their cancers.

Indexed as

cancermetastatic adenocarcinomapulmonary hypertensionright ventricular failure

Identifiers

PMID40054931
PMCPMC11911886

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.