Evidence map›Paper›PMID 40054927›Full record

ArticleJACC. Case reports2025

Pathologically Proven Papillary Fibroelastomas Attached to the Left Atrial Appendage and Pulmonary Vein Ridge.

Omar W Aboukhatwa, Elias Akiki, Hayat Memis, Kathryn F Larson, Eugene L Scharf, Lawrence J Sinak, Vuyisile T Nkomo, Melanie Bois, Joseph Maleszewski, Kyle Klarich and 1 more

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A rare papillary fibroelastoma arising from the Coumadin ridge.European heart journal. Imaging methods and practice · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Omar W AboukhatwaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Elias AkikiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Hayat MemisDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Kathryn F LarsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Eugene L ScharfDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Lawrence J SinakDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Vuyisile T NkomoDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Melanie BoisDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Joseph MaleszewskiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Kyle KlarichDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA. Electronic address: klarich.kyle@mayo.edu.
Reto KurmannDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillary fibroelastomas (PFEs) are the most common benign cardiac tumors, typically found on valvular surfaces but less frequently on extravalvular structures. Despite their benign nature, PFEs are associated with serious embolic events. This study analyzes 13 cases of pathology-proven PFEs in the left atrial appendage (LAA) and pulmonary vein ridge. Data on patient demographics, clinical presentations, imaging, and histopathology were reviewed. The median patient age was 73 years, with slight male predominance. Tumor sizes ranged from 2 mm to 20 mm. Twelve PFEs were detected via transesophageal echocardiography, and neurologic events were observed in 4 patients. This case series emphasizes the importance of maintaining a broad differential diagnosis for LAA masses because PFEs can easily be mistaken for thrombi.

Indexed as

cardiac tumorscoumadin ridgeechocardiographyleft atrial appendagepapillary fibroelastoma

Identifiers

PMID40054927
PMCPMC11911848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.