ArticleJACC. Case reports2025
Kratom Cardiotoxicity: Reversible Brugada Pattern and QTc Prolongation.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Self-medication of attention-deficit/hyperactivity disorder symptoms with psychoactive substances in adults: a scoping review of how symptom-relief motives are framed and operationalised across substances.Frontiers in psychiatry · 2026Pooled it
- Brugada Syndrome Unmasked by Kratom Use in a Young Man.JACC. Case reports · 2026Article
- Brugada Phenocopy Induced by Kratom Overdose.CJC open · 2026Article
- From kratom to 7-hydroxymitragynine: evolution of a natural remedy into a public-health threat.Pharmaceutical biology · 2025Review
- Chronic kratom use as a precipitant for acquired Brugada syndrome.HeartRhythm case reports · 2025Article
- Kratom-Associated Acute Right Ventricular Dysfunction: Diagnostic and Management Insights.JACC. Case reports · 2025Article
- A Kratomic Bomb: Cardiotoxicities From Mitragyna speciosa Extract.JACC. Case reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kratom is derived from Mitragyna speciosa and contains active alkaloids that bind opioid, alpha-2 adrenergic, and 5-HT2A receptors. In vitro studies show kratom can inhibit myocardial potassium channels. We present a patient who developed a reversible Brugada pattern and QT prolongation after self-treating his attention-deficit/hyperactivity disorder with kratom.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.