Evidence map›Paper›PMID 40054899›Full record

ArticleJACC. Case reports2025

Cocaine-Induced Sudden Cardiac Death Unravelling a SCN5A-Related Disease.

Raffaello Ditaranto, Guido Pelletti, Cesare Rossi, Mauro Biffi, Arthur A M Wilde, Elena Biagini, Antonietta D'Errico, Maddalena Graziosi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raffaello DitarantoCardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Guido PellettiUnit of Legal Medicine, Department of Medical and Surgical Sciences, University of Bologna, Italy.
Cesare RossiMedical Genetics Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Mauro BiffiCardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart.
Arthur A M WildeEuropean Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart; Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, the Netherlands.
Elena BiaginiCardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart. Electronic address: elena.biagini73@gmail.com.
Antonietta D'ErricoDepartment of Pathology. IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
Maddalena GraziosiCardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy; European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cocaine consumption is a significant global problem, with an estimated 20 million users worldwide. Sudden cardiac death is frequently reported in this population, particularly among individuals <40 years of age. The role of underlying inherited heart disorders in these cases remains largely unexplored. We report the case of a patient who suffered a cocaine-induced sudden death, where a dedicated program investigating unexplained deaths in the young identified a SCN5A-related disease. We hypothesize that inherited heart diseases may contribute to cocaine-induced sudden cardiac death and that a multidisciplinary program systematically evaluating sudden deaths in young individuals is essential to uncover this association and reveal hidden risk factors. Integrating clinical data with traditional pathological examination and molecular autopsy is crucial for determining the cause of death and enabling cascade screening in relatives.

Indexed as

autopsyBrugadachannelopathycocaineSCN5Asudden cardiac death

Identifiers

PMID40054899
PMCPMC11911831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.