ArticleBiological psychiatry2025
Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed With Positron Emission Tomography Imaging and Neuronally Derived Exosomes.
Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Effects of repeated nalfurafine and VZTK35 treatments on fentanyl/cocaine mixture self-administration in a rat drug-vs.-food choice procedure.Psychopharmacology · 2026Article
- Sex, social rank, and nicotine co-administration shape cocaine- and cocaethylene-induced reinstatement in monkeys.Frontiers in behavioral neuroscience · 2026Article
- The impact of sex, species, environmental context, and alternative reinforcers in animal models of cocaine use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- Context Matters: Sex and Social Status Impact Cocaine's Effects on Kappa Opioid Receptors.Biological psychiatry · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe current study utilized positron emission tomography (PET) imaging to examine how long-term cocaine self-administration (SA) and time off cocaine affected kappa opioid receptor (KOR) availability in the brain of previously cocaine-naïve monkeys. In addition, neuronally derived small extracellular vesicles (NDEs) were measured from plasma to identify peripheral measures of KORs.
methodsFemale (n = 6) and male (n = 7) cynomolgus monkeys, living in stable same-sex social groups, were trained to self-administer intravenous cocaine. PET imaging with the KOR selective agonist [
resultsThere were significant interactions between condition (100 mg/kg cocaine and 30 days off cocaine), sex, and social rank in KOR availability across 7 of 15 brain regions. More specifically, these interactions were associated with increased KOR availability following cocaine SA and after 30 days off cocaine in dominant females. In a subset of monkeys, no differences were observed in [
conclusionsThese findings extend previous research with socially housed monkeys on KORs and suggest that KOR may be a viable target for pharmacological interventions for cocaine misuse, especially in women.
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