ArticleBiological psychiatry2025
A Cross-Generational Methylomic Signature of Infant Maltreatment in Newborn Rhesus Macaques.
Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Early life experiences, the neural epigenome and affective disorder risk.Nature reviews. Neuroscience · 2026Review
- New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine.Diagnostics (Basel, Switzerland) · 2025Review
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Authors and funding
9 authors.
Funding
Abstract
backgroundEarly-life adversity (ELA) results in detrimental physical and mental health outcomes. The impact of ELA can reverberate across generations, with epigenetic modifications being one of the proposed biological correlates of exposure to ELA. Here, we bridge the translational gap between rodent models and clinical studies by utilizing a nonhuman primate model to study the cross-generational epigenetic and functional footprints of physical maltreatment and neglect.
methodsMethylomic profiling was performed using the Illumina MethylationEPIC array platform, adapted for rhesus macaques. A total of 339,081 individual methylation sites were compared between newborn offspring of maltreated (n = 14, 8 female) and nonmaltreated (n = 12, 5 female) mothers.
resultsWe identified 409 differentially methylated positions (DMPs) and 7 differentially methylated regions associated with the cross-generational impact of infant maltreatment. A subsequent pathway enrichment analysis revealed 78 enriched pathways. Neonatal blood cortisol levels were significantly lower in animals with a maltreated mother (maltreated n = 13, 7 female; control n = 9, 4 female). Of the 409 DMPs, 46 showed an association with blood cortisol levels, 19 of which were found to potentially mediate the association between ancestral infant maltreatment and decreased blood cortisol levels. Finally, 137 of the DMPs were associated with a human trait in the EWAS Atlas, including child abuse and glucocorticoid exposure.
conclusionsThese findings provide deeper insight into the role of epigenetic alterations across generations after environmental insults and how this may impact the development of phenotypic alterations in offspring of individuals exposed to maltreatment.
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